Methylphenidate - Pharmacology
Research News and Information

Sunday, November 22, 2009

Disagreements with implications: diverging discourses on the ethics of non-medical use of methylphenidate for performance enhancement.

4 Jul 2009 BACKGROUND: There is substantial evidence that methylphenidate (MPH; Ritalin), is being used by healthy university students for non-medical motives such as the improvement of concentration, alertness, and academic performance. The scope and ... Read more...

Behavioral response to methylphenidate challenge: influence of early life parental care.

29 Jun 2009 Rat studies have shown that pups subjected to suboptimal rearing conditions exhibited permanently dysregulated dopamine activity and altered behavioral responses to dopamine stimulation. In humans, heightened stress-induced mesoaccumbens dopamine ... Read more...

Chronic preexposure to methylphenidate cross-sensitizes methamphetamine in male Japanese quail.

29 Jun 2009 An increasing debate exists about the potential of exposure to methylphenidate increasing later risk of drug abuse. The objective of this study was to investigate whether chronic preexposure to methylphenidate would induce cross-sensitization to a ... Read more...

Latest indexed articles for 'Methylphenidate - Pharmacology'

These are the very latest articles for this heading:

• Age-related changes in motor subtle signs among girls and boys with ADHD. 11 Oct 2009
• Disagreements with implications: diverging discourses on the ethics of non-medical use of methylphenidate for performance enhancement. 4 Jul 2009
• Behavioral response to methylphenidate challenge: influence of early life parental care. 29 Jun 2009
• Chronic preexposure to methylphenidate cross-sensitizes methamphetamine in male Japanese quail. 29 Jun 2009
• Methylphenidate has positive hypocholesterolemic and hypotriglyceridemic effects: new data. 29 Jun 2009
• Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils. 15 Jun 2009
• Methylphenidate improves spatial memory of spontaneously hypertensive rats: evidence in behavioral and ultrastructural changes. 7 Jun 2009
• [Neuropsychopharmacological effects of methylphenidate] 30 May 2009
• Methylphenidate improves diminished error and feedback sensitivity in ADHD: An evoked heart rate analysis. 19 May 2009
• Controlled cortical impact injury influences methylphenidate-induced changes in striatal dopamine neurotransmission. 6 May 2009
• Sex differences in effectiveness of extended-release stimulant medication among adolescents with attention-deficit/hyperactivity disorder. 4 May 2009
• Drug reinforcement in a rat model of attention deficit/hyperactivity disorder--the Spontaneously Hypertensive Rat (SHR). 29 Apr 2009
• Dopaminergic modulation of brain systems subserving decision making under uncertainty: a study with fMRI and methylphenidate challenge. 29 Apr 2009
• Response to methylphenidate in children and adolescents with ADHD: does comorbid anxiety disorders matters? 14 Apr 2009
• Early long-term exposure with caffeine induces cross-sensitization to methylphenidate with involvement of DARPP-32 in adulthood of rats. 3 Apr 2009
• Dopamine-related genotypes and the dose-response effect of methylphenidate on eating in attention-deficit/hyperactivity disorder youths. 30 Mar 2009
• Effects of methylphenidate hydrochloride on the cardiovascular system in vivo and in vitro: a safety pharmacology study. 7 Mar 2009
• Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder. 27 Feb 2009
• Effects of psychostimulants on alertness and spatial bias in healthy participants. 27 Feb 2009
• Nicotinic receptors differentially modulate the induction and expression of behavioral sensitization to methylphenidate in rats. 18 Feb 2009

See a longer list of these articles.

Technical information about 'Methylphenidate'

Definition: A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE.

Chemical name: 2-Piperidineacetic acid, alpha-phenyl-, methyl ester

Registry Number: 113-45-1

Descriptor UI: D008774

Alternative terms: Methylphenidate; Dexmethylphenidate; Dexmethylphenidate Hydrochloride; Hydrochloride, Dexmethylphenidate; Focalin; Novartis Pharmaceutical Brand of Dexmethylphenidate Hydrochloride; Metadate; Equasym; Celltech Brand of Methylphenidate Hydrochloride; Methylphenidate Hydrochloride; Hydrochloride, Methylphenidate; Phenidylate; Ritalin; Novartis Brand 1 of Methylphenidate Hydrochloride; Ritaline; Cephalon Brand of Methylphenidate Hydrochloride; Ritalin-SR; Ritalin SR; Novartis Brand 2 of Methylphenidate Hydrochloride; Tsentedrin; Centedrin; Daytrana; Methylin; Mallinckrodt Brand of Methylphenidate Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Dopamine Uptake Inhibitors; Central Nervous System Stimulants;

Tree Number: D02.241.223.601.600; D03.383.621.460;

Online Note: use METHYLPHENIDATE to search PHENIDYLATE 1978-94

History Note: PHENIDYLATE was see METHYLPHENIDATE 1978-94