Methylphenidate - Toxicity
Research News and Information

Monday, November 23, 2009

[Differences in neuronal toxicity and its molecular mechanisms between methamphetamine and methylphenidate]

30 May 2009 Methylphenidate (MPH) is commonly used in the treatment of narcolepsy and attention deficit/hyperactivity disorder (AD/HD) in Japan. MPH has been also known to have psychostimulus effects similar to methamphetamine (METH). In the present study, we ... Read more...

Juvenile methylphenidate exposure and factors that influence incentive processing.

15 Apr 2009 Methylphenidate (MPH) is one of the few psychotropic agents approved for use in pediatric populations, underscoring the importance of elucidating any long-term consequences following exposure to this agent. Here, we examined the influence of several ... Read more...

Chronic oral methylphenidate induces post-treatment impairment in recognition and spatial memory in adult rats.

21 Jan 2009 Recent pre-clinical research has indicated that chronic treatment with methylphenidate (Ritalin) in young animals can result in lasting and potentially detrimental alterations in brain function that can persist into adulthood. Chronic ... Read more...

Latest indexed articles for 'Methylphenidate - Toxicity'

These are the very latest articles for this heading:

• [Differences in neuronal toxicity and its molecular mechanisms between methamphetamine and methylphenidate] 30 May 2009
• Juvenile methylphenidate exposure and factors that influence incentive processing. 15 Apr 2009
• Chronic oral methylphenidate induces post-treatment impairment in recognition and spatial memory in adult rats. 21 Jan 2009
• Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. 29 Nov 2008
• Developmental toxicity assessment of d,l-methylphenidate and d-methylphenidate in rats and rabbits. 29 Sep 2008
• Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice. 29 Sep 2008
• [Drug-induced psychosis after intake of a modified--release formulation of methylphenidate] 25 May 2008
• Serotonin syndrome induced by augmentation of SSRI with methylphenidate. 30 Mar 2008
• Juvenile toxicity assessment of d,l-methylphenidate in rats. 30 Jan 2008
• Acute and sub-chronic functional neurotoxicity of methylphenidate on neural networks in vitro. 16 Jun 2007
• Early exposure to methylphenidate increases fear responses in an aversive context in adult rats. 30 Mar 2007
• Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test. 5 Jul 2006
• Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro. 30 May 2006
• [Methylphenidate-induced cytogenetic alterations?] 29 Apr 2006
• Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine. 30 Oct 2005
• NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of methylphenidate. 30 Jul 2005
• Stimulant-atypical antipsychotic interaction and acute dystonia. 30 May 2005
• Toxicokinetic assessment of methylphenidate (Ritalin) enantiomers in pregnant rats and rabbits. 30 May 2004
• Toxicokinetic assessment of methylphenidate (Ritalin) in a 13-week oral toxicity study in dogs. 30 Dec 2003
• D-Methylphenidate is non-genotoxic in in vitro and in vivo assays. 7 May 2003

See a longer list of these articles.

Technical information about 'Methylphenidate'

Definition: A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE.

Chemical name: 2-Piperidineacetic acid, alpha-phenyl-, methyl ester

Registry Number: 113-45-1

Descriptor UI: D008774

Alternative terms: Methylphenidate; Dexmethylphenidate; Dexmethylphenidate Hydrochloride; Hydrochloride, Dexmethylphenidate; Focalin; Novartis Pharmaceutical Brand of Dexmethylphenidate Hydrochloride; Metadate; Equasym; Celltech Brand of Methylphenidate Hydrochloride; Methylphenidate Hydrochloride; Hydrochloride, Methylphenidate; Phenidylate; Ritalin; Novartis Brand 1 of Methylphenidate Hydrochloride; Ritaline; Cephalon Brand of Methylphenidate Hydrochloride; Ritalin-SR; Ritalin SR; Novartis Brand 2 of Methylphenidate Hydrochloride; Tsentedrin; Centedrin; Daytrana; Methylin; Mallinckrodt Brand of Methylphenidate Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Dopamine Uptake Inhibitors; Central Nervous System Stimulants;

Tree Number: D02.241.223.601.600; D03.383.621.460;

Online Note: use METHYLPHENIDATE to search PHENIDYLATE 1978-94

History Note: PHENIDYLATE was see METHYLPHENIDATE 1978-94