Mice, Mutant Strains
Research News and Information

Saturday, November 21, 2009

Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus.

30 Oct 2009 Neurofibromatosis 1 (NF1) is a common single-gene disorder that causes learning impairments in patients. Neurofibromin encoded by the NF1 causal gene regulates Ras/MAPK and cAMP signaling pathways. These signaling pathways play critical roles in ... Read more...

The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice.

30 Oct 2009 The Ron receptor tyrosine kinase is overexpressed in approximately half of all human colon cancers. Increased Ron expression positively correlates with tumor progression, and reduction of Ron levels in human colon adenocarcinoma cells reverses their ... Read more...

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.

17 Oct 2009 ZAP-70 is critical for T cell receptor (TCR) signaling. Tyrosine to phenylalanine mutations of Y315 and Y319 in ZAP-70 suggest these residues function to recruit downstream effector molecules, but mutagenesis and crystallization studies reveal that ... Read more...

Latest indexed articles for 'Mice, Mutant Strains'

These are the very latest articles for this heading:

• Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus. 30 Oct 2009
• The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice. 30 Oct 2009
• A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. 17 Oct 2009
• Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. 13 Oct 2009
• TCR down-regulation controls T cell homeostasis. 13 Oct 2009
• Evolutionary development of the middle ear in Mesozoic therian mammals. 7 Oct 2009
• Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. 5 Oct 2009
• Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus. 5 Oct 2009
• T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. 4 Oct 2009
• Antigen-dependent rescue of nose-associated lymphoid tissue (NALT) development independent of LTbetaR and CXCR5 signaling. 29 Sep 2009
• Oxygen sensing in the carotid body. 29 Sep 2009
• Renaissance for mouse models of human hematopoiesis and immunobiology. 29 Sep 2009
• Ex vivo expanded telomerase-specific T cells are effective in an orthotopic mouse model for pancreatic adenocarcinoma. 29 Sep 2009
• Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus. 28 Sep 2009
• Characterization of the chromosomal inversion associated with the Koa mutation in the mouse revealed the cause of skeletal abnormalities. 20 Sep 2009
• The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. 18 Sep 2009
• Ocular abnormalities in mice lacking the immunoglobulin superfamily member Cdo. 13 Sep 2009
• Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis. 12 Sep 2009
• Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. 12 Sep 2009
• Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. 12 Sep 2009

See a longer list of these articles.

Technical information about 'Mice, Mutant Strains'

Definition: Mice bearing mutant genes which are phenotypically expressed in the animals.

Descriptor UI: D008817

Alternative terms: Mice, Mutant Strains; Mutant Strains Mice; Strains Mice, Mutant; Mutant Mouse Strain; Mouse Strain, Mutant; Mouse Strains, Mutant; Mutant Mouse Strains; Strain, Mutant Mouse; Strains, Mutant Mouse; Mutant Strains of Mice; Mice Mutant Strain; Mice Mutant Strains; Mouse, Mutant Strain; Mutant Strain Mouse; Strain Mouse, Mutant; Mutant Strain of Mouse; Mouse Mutant Strain; Mouse Mutant Strains;

Allowable Qualifiers: abnormalities; anatomy & histology; blood; cerebrospinal fluid; classification; embryology; genetics; growth & development; immunology; injuries; metabolism; microbiology; parasitology; physiology; psychology; surgery; urine; virology;

Tree Number: B01.150.900.649.865.635.505.500.550;

History Note: 79

Technical Notes: GEN or unspecified; prefer specifics; NIM when exper animal: no qualif; when IM, qualif permitted; do not forget also to check tag MICE