Migraine Disorders
Research News and Information

Sunday, November 22, 2009

Tonabersat, a novel gap-junction modulator for the prevention of migraine.

30 Oct 2009 Migraine is a common, recurrent, primary headache disorder associated with significant morbidity as well as high direct and indirect costs. Despite its impact, only a proportion of migraineurs who meet criteria for prophylactic treatment take ... Read more...

Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine.

30 Oct 2009 Tonabersat is a novel benzopyran derivative that blocks the cortical spreading depression proposed to be associated with migraine attacks. The ability of single oral doses of 15, 25, 40 and 80 mg of tonabersat to relieve the symptoms of moderate to ... Read more...

Efficacy and safety of tonabersat, a gap-junction modulator, in the acute treatment of migraine: a double-blind, parallel-group, randomized study.

30 Oct 2009 The ability of tonabersat to relieve the symptoms of migraine attacks with or without aura was evaluated in a randomized, double-blind, placebo-controlled, multicentre, parallel-group study. Patients received 20 or 40 mg of tonabersat, or 50 mg of ... Read more...

Latest indexed articles for 'Migraine Disorders'

These are the very latest articles for this heading:

• Tonabersat, a novel gap-junction modulator for the prevention of migraine. 30 Oct 2009
• Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. 30 Oct 2009
• Efficacy and safety of tonabersat, a gap-junction modulator, in the acute treatment of migraine: a double-blind, parallel-group, randomized study. 30 Oct 2009
• Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. 30 Oct 2009
• Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. 30 Oct 2009
• Unpublished clinical trials with sumatriptan. 29 Oct 2009
• Patent foramen ovale closure and migraines: muddy waters. 13 Oct 2009
• Neurons of the dopaminergic/calcitonin gene-related peptide A11 cell group modulate neuronal firing in the trigeminocervical complex: an electrophysiological and immunohistochemical study. 5 Oct 2009
• Contraception for women. First consultation for the pill. 3 Oct 2009
• Cervicogenic headache: a pain in the neck for some neurologists? 29 Sep 2009
• Rizatriptan induced acute on top of chronic ischemic colitis. 29 Sep 2009
• Lacrimation, conjunctival injection, nasal symptoms... cluster headache, migraine and cranial autonomic symptoms in primary headache disorders -- what's new? 29 Sep 2009
• [The effect of autogenic training combined with organ formula and movement therapy on spontaneous and provoked migraine headaches] 28 Sep 2009
• Probable fluoxetine-induced carotidynia. 24 Sep 2009
• Randomized, controlled trial of telcagepant for the acute treatment of migraine. 20 Sep 2009
• Two-stage case-control association study of dopamine-related genes and migraine. 19 Sep 2009
• [Is there a bridge between migraine and familial mesial temporal lobe epilepsy?] 14 Sep 2009
• Cessation of sporadic hemiplegic migraine attacks after patent foramen ovale closure. 14 Sep 2009
• [Migraine can signal a risk for heart and brain] 8 Sep 2009
• Air pollution and hospitalization for headache in Chile. 7 Sep 2009

See a longer list of these articles.

Technical information about 'Migraine Disorders'

Definition: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Descriptor UI: D008881

Alternative terms: Migraine Disorders; Disorder, Migraine; Disorders, Migraine; Migraine Disorder; Migraine; Migraines; Migraine Headache; Headache, Migraine; Headaches, Migraine; Migraine Headaches; Acute Confusional Migraine; Acute Confusional Migraines; Migraine, Acute Confusional; Migraines, Acute Confusional; Status Migrainosus; Hemicrania Migraine; Hemicrania Migraines; Migraine, Hemicrania; Migraines, Hemicrania; Migraine Variant; Migraine Variants; Variant, Migraine; Variants, Migraine; Sick Headache; Headache, Sick; Headaches, Sick; Sick Headaches; Abdominal Migraine; Abdominal Migraines; Migraine, Abdominal; Migraines, Abdominal; Cervical Migraine Syndrome; Cervical Migraine Syndromes; Migraine Syndrome, Cervical; Migraine Syndromes, Cervical;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.546.399.750;

History Note: 2006 (1963)

Technical Notes: note many specifics; use word of text