Mitochondria - Drug effects
Research News and Information

Friday, March 12, 2010

Kinetics of transport and phosphorylation of glucose in cancer cells.

29 Nov 2009 Metabolic control analysis of tumor glycolysis has indicated that hexokinase (HK) and glucose transporter (GLUT) exert the main flux control (71%). To understand why they are the main controlling steps, the GLUT and HK kinetics and the contents of ... Read more...

NF-kappaB independent activation of a series of proinflammatory genes by hydrogen sulfide.

30 Oct 2009 A stress response has the potential to induce greater resistance to subsequent stress damage. We tested whether hydrogen sulfide (H(2)S), an important signaling molecule, also used therapeutically, and known for detrimental effects, might induce a ... Read more...

Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells.

30 Oct 2009 Cardiomyocyte apoptosis is a component of cardiac remodeling that can contribute to heart failure in obesity. A role for leptin in mediating this process has been suggested and the objective of this work was to investigate the effect of leptin on ... Read more...

Latest indexed articles for 'Mitochondria - Drug effects'

These are the very latest articles for this heading:

• Kinetics of transport and phosphorylation of glucose in cancer cells. 29 Nov 2009
• NF-kappaB independent activation of a series of proinflammatory genes by hydrogen sulfide. 30 Oct 2009
• Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
• W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac. 30 Oct 2009
• Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. 21 Oct 2009
• Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. 11 Oct 2009
• Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
• Linking fatty acid stress to beta-cell mitochondrial dynamics. 29 Sep 2009
• Combination treatment of hydrogen peroxide and X-rays induces apoptosis in human prostate cancer PC-3 cells. 29 Sep 2009
• Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. 29 Sep 2009
• Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. 9 Sep 2009
• Interferon-gamma bolsters CD95/Fas-mediated apoptosis of astroglioma cells. 7 Sep 2009
• 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. 6 Sep 2009
• The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. 30 Aug 2009
• Proteomic analysis of changes in mitochondrial protein expression during fruit senescence. 30 Aug 2009
• Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. 30 Aug 2009
• Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation. 30 Aug 2009
• Molecular mechanisms of ginsenoside Rp1-mediated growth arrest and apoptosis. 30 Aug 2009
• Pure red cell precursor toxicity by linezolid in a pediatric case. 30 Aug 2009
• Pamidronate-induced kidney injury in a patient with metastatic breast cancer. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Mitochondria'

Definition: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)

Descriptor UI: D008928

Alternative terms: Mitochondria; Mitochondrion; Mitochondrial Contraction; Contraction, Mitochondrial; Contractions, Mitochondrial; Mitochondrial Contractions;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology; genetics;

Tree Number: A11.284.430.214.190.875.564; A11.284.835.626;

History Note: MITOCHONDRIAL CONTRACTION was heading 1969-96 (was see under MITOCHONDRIA 1975, was Prov 1969-74)

Technical Notes: A 11 qualif except /cytol; /genet permitted; coord with organ /metab (IM) but not also organ /ultrastruct for metab studies, coord with organ /ultrastruct (IM) for morphol studies: TN 126; mitochondria of vasc or smooth musc tissue goes under MITOCHONDRIA, MUSCLE & do not coord with MUSCLE, SMOOTH or MUSCLE, SMOOTH, VASCULAR unless particularly discussed & then probably only NIM