Mitogen-Activated Protein Kinase 1 - Genetics
Research News and Information

Monday, November 23, 2009

Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.

13 Oct 2009 Signals initiated through the TCR during development can result in either survival and differentiation or cell death. High affinity signals that induce death elicit a robust yet transient activation of signaling pathways, including Erk, whereas low ... Read more...

[The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain]

28 Sep 2009 Aging itself is considered as a major risk factor of dementia. The prevalence of the Alzheimer's disease (AD) is increasing exponentially after the age of 65 and doubles every 5 years. The major aim of our present research was to examine the effect ... Read more...

Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors.

30 Aug 2009 Interleukin-12 (IL-12)-deficiency promotes photocarcinogenesis in mice; however, the molecular mechanisms underlying this effect have not been fully elucidated. Here, we report that long-term exposure to ultraviolet (UV) radiation resulted in ... Read more...

Latest indexed articles for 'Mitogen-Activated Protein Kinase 1 - Genetics'

These are the very latest articles for this heading:

• Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. 13 Oct 2009
• [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain] 28 Sep 2009
• Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors. 30 Aug 2009
• Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. 12 Aug 2009
• VEGF and RANKL regulation of NFATc1 in heart valve development. 4 Aug 2009
• CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1/2 MAPK pathway. 21 Jul 2009
• MEK1 mutations, but not ERK2 mutations, occur in melanomas and colon carcinomas, but none in thyroid carcinomas. 7 Jul 2009
• A one-step method to identify MAP kinase residues involved in inactivation by tyrosine- and dual-specificity protein phosphatases. 3 Jul 2009
• The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. Jul 2009
• Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2. 21 Jun 2009
• Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK. 11 Jun 2009
• Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations. 10 Jun 2009
• Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of human colon cancer cells. 9 Jun 2009
• Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. 4 Jun 2009
• Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. 3 Jun 2009
• Insufficient activity of MAPK pathway is a key monitor of Kidney-Yang Deficiency Syndrome. 30 May 2009
• Mitogen-activated protein kinases are involved in tumor necrosis factor alpha production in macrophages infected with Orientia tsutsugamushi. 30 May 2009
• Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA. 25 May 2009
• Raf-independent, PP2A-dependent MEK activation in response to ERK silencing. 20 May 2009
• Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. 19 May 2009

See a longer list of these articles.

Technical information about 'Mitogen-Activated Protein Kinase 1'

Definition: A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.

Registry Number: EC 2.7.1.37

Descriptor UI: D019950

Alternative terms: Mitogen-Activated Protein Kinase 1; Mitogen Activated Protein Kinase 1; Extracellular Signal-Regulated Kinase 2; Extracellular Signal Regulated Kinase 2; MAP Kinase 2; MAPK1 Mitogen-Activated Protein Kinase; MAPK1 Mitogen Activated Protein Kinase; p42(Mitogen-Activated Protein Kinase); Mitogen-Activated Protein Kinase 2; Mitogen Activated Protein Kinase 2; p42 MAP Kinase; MAP Kinase, p42; p42(Mapk); p42(Mapk) Kinase; p42 MAPK; MAPK2 Mitogen-Activated Protein Kinase; MAPK2 Mitogen Activated Protein Kinase; p41 Mitogen-Activated Protein Kinase; p41 Mitogen Activated Protein Kinase; p41 MAPK; p40 Mitogen-Activated Protein Kinase; p40 Mitogen Activated Protein Kinase; ERK2 Brain Kinase PK40;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700.567.342.500; D08.811.913.696.620.682.700.646.750.249.500; D12.644.360.450.169.500; D12.776.476.450.169.500;

History Note: 2005(1992)

Technical Notes: Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases