Mitogen-Activated Protein Kinase 1
Research News and Information

Saturday, November 21, 2009

p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death.

29 Nov 2009 Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein ... Read more...

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.

13 Nov 2009 Mutations in KRAS or BRAF frequently manifest in constitutive activation of the MEK1/2-ERK1/2 signalling pathway. The MEK1/2-selective inhibitor, AZD6244 (ARRY-142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour ... Read more...

The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats.

30 Oct 2009 BACKGROUND: Surgical trauma contributes to postoperative immune suppression, which is associated with an increased susceptibility to subsequent infections. Electroacupuncture (EA) can alleviate pain and exert immunoregulatory effects. However, the ... Read more...

Latest indexed articles for 'Mitogen-Activated Protein Kinase 1'

These are the very latest articles for this heading:

• p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. 29 Nov 2009
• Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. 13 Nov 2009
• The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats. 30 Oct 2009
• Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. 13 Oct 2009
• Prion protein and its ligand stress inducible protein 1 regulate astrocyte development. 29 Sep 2009
• Curcumin: a potential radio-enhancer in head and neck cancer. 29 Sep 2009
• Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice. 29 Sep 2009
• [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain] 28 Sep 2009
• Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 15 Sep 2009
• Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells. 8 Sep 2009
• Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. 6 Sep 2009
• Docosahexaenoic acid down-regulates endothelial Nox 4 through a sPLA2 signalling pathway. 4 Sep 2009
• Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. 2 Sep 2009
• Impact of the transfer of sFlt-1 gene fragments on the ERK1/2 pathway of VEGF in vitro. 30 Aug 2009
• Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis. 30 Aug 2009
• Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors. 30 Aug 2009
• p75 neurotrophin receptor is implicated in the ability of neurotrophin-3 to negatively modulate activated ERK1/2 signaling in TrkA-expressing adult sensory neurons. 30 Aug 2009
• Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes. 30 Aug 2009
• Nm23-H1 promotes adhesion of CAL 27 cells in vitro. 30 Aug 2009
• Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages. 29 Aug 2009

See a longer list of these articles.

Technical information about 'Mitogen-Activated Protein Kinase 1'

Definition: A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.

Registry Number: EC 2.7.1.37

Descriptor UI: D019950

Alternative terms: Mitogen-Activated Protein Kinase 1; Mitogen Activated Protein Kinase 1; Extracellular Signal-Regulated Kinase 2; Extracellular Signal Regulated Kinase 2; MAP Kinase 2; MAPK1 Mitogen-Activated Protein Kinase; MAPK1 Mitogen Activated Protein Kinase; p42(Mitogen-Activated Protein Kinase); Mitogen-Activated Protein Kinase 2; Mitogen Activated Protein Kinase 2; p42 MAP Kinase; MAP Kinase, p42; p42(Mapk); p42(Mapk) Kinase; p42 MAPK; MAPK2 Mitogen-Activated Protein Kinase; MAPK2 Mitogen Activated Protein Kinase; p41 Mitogen-Activated Protein Kinase; p41 Mitogen Activated Protein Kinase; p41 MAPK; p40 Mitogen-Activated Protein Kinase; p40 Mitogen Activated Protein Kinase; ERK2 Brain Kinase PK40;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700.567.342.500; D08.811.913.696.620.682.700.646.750.249.500; D12.644.360.450.169.500; D12.776.476.450.169.500;

History Note: 2005(1992)

Technical Notes: Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases