Mitogen-Activated Protein Kinase 3 - Genetics
Research News and Information

Sunday, November 22, 2009

Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.

13 Oct 2009 Signals initiated through the TCR during development can result in either survival and differentiation or cell death. High affinity signals that induce death elicit a robust yet transient activation of signaling pathways, including Erk, whereas low ... Read more...

The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA.

15 Sep 2009 The amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. ... Read more...

Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors.

30 Aug 2009 Interleukin-12 (IL-12)-deficiency promotes photocarcinogenesis in mice; however, the molecular mechanisms underlying this effect have not been fully elucidated. Here, we report that long-term exposure to ultraviolet (UV) radiation resulted in ... Read more...

Latest indexed articles for 'Mitogen-Activated Protein Kinase 3 - Genetics'

These are the very latest articles for this heading:

• Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. 13 Oct 2009
• The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. 15 Sep 2009
• Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors. 30 Aug 2009
• Tumor necrosis factor-alpha inhibits Schwann cell proliferation by up-regulating Src-suppressed protein kinase C substrate expression. 16 Aug 2009
• VEGF and RANKL regulation of NFATc1 in heart valve development. 4 Aug 2009
• CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1/2 MAPK pathway. 21 Jul 2009
• Effect of the DEF motif on phosphorylation of peptide substrates by ERK. 13 Jul 2009
• The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. Jul 2009
• Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans. 17 Jun 2009
• Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK. 11 Jun 2009
• Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations. 10 Jun 2009
• Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of human colon cancer cells. 9 Jun 2009
• Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. 4 Jun 2009
• Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. 3 Jun 2009
• The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity. 30 May 2009
• Mitogen-activated protein kinases are involved in tumor necrosis factor alpha production in macrophages infected with Orientia tsutsugamushi. 30 May 2009
• Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA. 25 May 2009
• Raf-independent, PP2A-dependent MEK activation in response to ERK silencing. 20 May 2009
• Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. 19 May 2009
• The mechanism of butyrate-induced collagen biosynthesis in cultured fibroblasts. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Mitogen-Activated Protein Kinase 3'

Definition: A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.

Registry Number: EC 2.7.1.37

Descriptor UI: D048052

Alternative terms: Mitogen-Activated Protein Kinase 3; Mitogen Activated Protein Kinase 3; Meiosis-Activated Myelin Basic Protein Kinase p44(mpk); Microtubule-Associated Protein-2 Kinase; Kinase, Microtubule-Associated Protein-2; Microtubule Associated Protein 2 Kinase; p44 MAPK; Extracellular Signal-Regulated Kinase 1; Extracellular Signal Regulated Kinase 1; PSTkinase p44mpk; p44mpk, PSTkinase; ERK1 Kinase; Kinase, ERK1; MAPK3 Mitogen-Activated Protein Kinase; MAPK3 Mitogen Activated Protein Kinase; Protein-Serine-Threonine Kinase p44(mpk);

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700.567.342.750; D08.811.913.696.620.682.700.646.750.249.750; D12.644.360.450.169.750; D12.776.476.450.169.750;

History Note: 2005(2000)