Molecular Conformation
Research News and Information

Sunday, November 22, 2009

Mimics of the self-assembling chlorosomal bacteriochlorophylls: regio- and stereoselective synthesis and stereoanalysis of acyl(1-hydroxyalkyl)porphyrins.

12 Oct 2009 Diacylation of copper 10,20-bis(3,5-di-tert-butylphenylporphyrin) using Friedel-Crafts conditions at short reaction times, high concentrations of catalyst, and 0-4 degrees C affords only the 3,17-diacyl-substituted porphyrins, out of the 12 possible ... Read more...

Molecular dynamics study of non-nucleoside reverse transcriptase inhibitor 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/rilpivirine) aggregates: correlation between amphiphilic properties of the drug and oral bioavailability.

6 Oct 2009 The non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278/rilpivirine is an anti-AIDS therapeutic agent with high oral bioavailability despite its high hydrophobicity. Previous studies established a correlation between ability of the drug ... Read more...

Synthesis, conformational analysis, and biological evaluation of 19-nor-vitamin D3 analogues with A-ring modifications.

6 Oct 2009 We have synthesized several isomers of 19-nor-vitamin D analogues possessing a hydroxy group at C-2 as well as novel derivatives bearing an epoxy substituent at the A-ring. All vitamins were prepared in convergent syntheses utilizing the modified ... Read more...

Latest indexed articles for 'Molecular Conformation'

These are the very latest articles for this heading:

• Mimics of the self-assembling chlorosomal bacteriochlorophylls: regio- and stereoselective synthesis and stereoanalysis of acyl(1-hydroxyalkyl)porphyrins. 12 Oct 2009
• Molecular dynamics study of non-nucleoside reverse transcriptase inhibitor 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/rilpivirine) aggregates: correlation between amphiphilic properties of the drug and oral bioavailability. 6 Oct 2009
• Synthesis, conformational analysis, and biological evaluation of 19-nor-vitamin D3 analogues with A-ring modifications. 6 Oct 2009
• Assembly mechanisms of RNA pseudoknots are determined by the stabilities of constituent secondary structures. 3 Oct 2009
• Trigger factor finds new jobs and contacts. 29 Sep 2009
• Extensive conformational searches of 13 representative dipeptides and an efficient method for dipeptide structure determinations based on amino acid conformers. 29 Sep 2009
• Natural abundant solid state NMR studies in designed tripeptides for differentiation of multiple conformers. 29 Sep 2009
• Arthropod nuclear receptors and their role in molting. 28 Sep 2009
• High-resolution structure of the rotor ring of a proton-dependent ATP synthase. 25 Sep 2009
• Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure. 22 Sep 2009
• Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. 22 Sep 2009
• Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification. 22 Sep 2009
• Structural artifacts in protein-ligand X-ray structures: implications for the development of docking scoring functions. 22 Sep 2009
• Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. 18 Sep 2009
• Structural and kinetic determinants of protease substrates. 18 Sep 2009
• Pseudomerohedrally twinned monoclinic structure of unfolded 'free' nonactin: comparative analysis of its large conformational change upon encapsulation of alkali metal ions. 17 Sep 2009
• Exploring conformational modes of macromolecular assemblies by multiparticle cryo-EM. 16 Sep 2009
• Structure and conformational analysis of a bidentate pro-ligand, C21H34N2S2, from powder synchrotron diffraction data and solid-state DFTB calculations. 15 Sep 2009
• Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. 13 Sep 2009
• Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. 11 Sep 2009

See a longer list of these articles.

Technical information about 'Molecular Conformation'

Definition: The characteristic three-dimensional shape of a molecule.

Descriptor UI: D008968

Alternative terms: Molecular Conformation; Conformation, Molecular; Conformations, Molecular; Molecular Conformations; Configuration, Molecular; Configurations, Molecular; Molecular Configurations; Molecular Structure, Three Dimensional; Three Dimensional Molecular Structure; 3D Molecular Structure; 3D Molecular Structures; Molecular Structure, 3D; Molecular Structures, 3D; Structure, 3D Molecular; Structures, 3D Molecular; Molecular Configuration;

Related Mesh Headings: Models, Molecular;

Allowable Qualifiers: drug effects; radiation effects;

Tree Number: G02.111.570.790; G02.575.500; G02.842.575.500;

History Note: 73

Technical Notes: general; prefer specifics; do not confuse with MOLECULAR STRUCTURE; DF: MOL CONFORMATION