Molecular Diagnostic Techniques
Research News and Information

Monday, November 23, 2009

Gene expression profiling: decoding breast cancer.

29 Nov 2009 Gene expression assays that are used in daily clinical practice for treating early breast cancer patients have been introduced in the clinic only recently. This review discusses the development of these arrays, summarizes the validation of those ... Read more...

Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics.

29 Sep 2009 Epidermal growth factor receptor (EGFR) is commonly affected in cancer, generally in the form of an increase in DNA copy number and/or as mutation variants [e.g., EGFR variant III (EGFRvIII), an in-frame deletion of exons 2-7]. While detection of ... Read more...

An audit of genetic testing in diagnosis of inherited retinal disorders: a prerequisite for gene-specific intervention.

30 Aug 2009 BACKGROUND: There has been an exponential increase in the number of genes implicated in inherited retinal disease over the last decade, but the genetic and phenotypic heterogeneity limited mutation detection. The high cost of sequencing and long ... Read more...

Latest indexed articles for 'Molecular Diagnostic Techniques'

These are the very latest articles for this heading:

• Gene expression profiling: decoding breast cancer. 29 Nov 2009
• Growing calls in United States, Europe to improve regulation of genetic testing. 5 Oct 2009
• Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics. 29 Sep 2009
• The role of community molecular diagnostics laboratories in the H1N1 pandemic. 30 Aug 2009
• An audit of genetic testing in diagnosis of inherited retinal disorders: a prerequisite for gene-specific intervention. 30 Aug 2009
• HLA-DRneg patients without acute promyelocytic leukemia show distinct immunophenotypic, genetic, molecular, and cytomorphologic characteristics compared to acute promyelocytic leukemia. 30 Aug 2009
• New molecular classifications of breast cancer. 30 Aug 2009
• Genetic counseling and genetic testing in ophthalmology. 30 Aug 2009
• Childhood macular dystrophies. 30 Aug 2009
• Infectious causes of cancer and their detection. 9 Aug 2009
• [Differential diagnosis of chorea] 30 Jul 2009
• [Mutation-specific treatments for Duchenne muscular dystrophy] 30 Jul 2009
• Comparison of fluorescence in situ hybridization, hybrid capture 2 and polymerase chain reaction for the detection of high-risk human papillomavirus in cervical cytology specimens. 30 Jul 2009
• The risk of a second diagnostic window with 4th generation HIV assays: Two cases. 30 Jul 2009
• Comparative evaluation of the AccuProbe Group B Streptococcus Culture Test, the BD GeneOhm Strep B assay, and culture for detection of group B streptococci in pregnant women. 27 Jul 2009
• Evaluation of a commercial MRSA assay when multiple MRSA strains are causing epidemics. 23 Jul 2009
• Evaluation of the Abbott investigational use only RealTime hepatitis C virus (HCV) assay and comparison to the Roche TaqMan HCV analyte-specific reagent assay. 20 Jul 2009
• Mastitis detection: current trends and future perspectives. 14 Jul 2009
• Prevalence and management of invalid GeneXpert enterovirus results obtained with cerebrospinal fluid samples: a 2-year study. 13 Jul 2009
• Quantification of hepatitis C virus (HCV) RNA in a multicenter study: implications for management of HCV genotype 1-infected patients. 13 Jul 2009

See a longer list of these articles.

Technical information about 'Molecular Diagnostic Techniques'

Definition: MOLECULAR BIOLOGY techniques used in the diagnosis of disease. Included are such techniques as IN SITU HYBRIDIZATION of chromosomes for CYTOGENETIC ANALYSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS of gene expression patterns in disease states; identification of pathogenic organisms by analysis of species specific DNA sequences; and detection of mutations with POLYMERASE CHAIN REACTION.

Descriptor UI: D025202

Alternative terms: Molecular Diagnostic Techniques; Diagnostic Technique, Molecular; Diagnostic Techniques, Molecular; Molecular Diagnostic Technique; Technique, Molecular Diagnostic; Techniques, Molecular Diagnostic; Molecular Diagnostic Technics; Diagnostic Technic, Molecular; Diagnostic Technics, Molecular; Molecular Diagnostic Technic; Technic, Molecular Diagnostic; Technics, Molecular Diagnostic; Molecular Diagnostic Testing; Diagnostic Testing, Molecular; Testing, Molecular Diagnostic;

Related Mesh Headings: Genetic Screening; Molecular Probes; Cytogenetic Analysis;

Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;

Tree Number: E05.200.880; E05.393.520;

History Note: 2002; for MOLECULAR DIAGNOSTIC TESTING use CYTOGENETIC ANALYSIS 2000-2001

Technical Notes: coord with specific technique