Molsidomine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage.

29 Jun 2009 There is mounting evidence that peroxynitrite (ONOO(-)) is closely related to the pathogenesis of various diseases. As a pharmacological strategy aimed at preventing ONOO(-)-mediated toxicity, the protective activity of Forsythia suspensa (Thunb.) ... Read more...

The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat.

6 Jun 2009 Nitric oxide (NO) is considered as an intracellular messenger in the brain. Its involvement in learning and memory processes has been proposed. Compounds that inhibit NO synthase (NOS), the key synthesizing enzyme, may inhibit cognition, while NO ... Read more...

Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage.

30 May 2009 Peroxynitrite (PN)-mediated mitochondrial dysfunction has been implicated in the secondary injury process after traumatic spinal cord injury (SCI). This study investigated the detrimental effects of the PN donor SIN-1 (3-morpholinosydnonimine) on ... Read more...

Latest indexed articles for 'Molsidomine - Pharmacology'

These are the very latest articles for this heading:

• Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage. 29 Jun 2009
• The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat. 6 Jun 2009
• Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage. 30 May 2009
• Peroxynitrite induces gene expression in intervertebral disc cells. 13 May 2009
• PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major. 23 Apr 2009
• Nitric oxide- and cGMP-active compounds affect the discharge of substantia nigra pars reticulata neurons: in vivo evidences in the rat. 5 Apr 2009
• Cyclic guanosine monophosphate signaling cascade mediates pigment aggregation in freshwater shrimp chromatophores. 30 Mar 2009
• Nitric oxide donor-mediated inhibition of phosphorylation shows that light-mediated degradation of photosystem II D1 protein and phosphorylation are not tightly linked. 16 Mar 2009
• Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro. 24 Feb 2009
• Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: a neurochemical study . 30 Jan 2009
• Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. 4 Jan 2009
• The effects of nitric oxide donor molsidomine on skeletal muscle damage in a rat hind limb model of ischemia-reperfusion. 11 Nov 2008
• Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury. 5 Nov 2008
• Morphological and physiological study of the cardiac NOS/NO system in the Antarctic (Hb-/Mb-) icefish Chaenocephalus aceratus and in the red-blooded Trematomus bernacchii. 4 Nov 2008
• Luminescence experiments involved in the mechanism of streptozotocin diabetes and cataract formation. 30 Oct 2008
• [Recent findings on nitrates: their action, bioactivation and development of tolerance] 20 Oct 2008
• Physiopathological effects of the NO donor 3-morpholinosydnonimine on rat cortical synaptosomes. 6 Oct 2008
• Role of the NMDA receptor and nitric oxide in memory reconsolidation of cocaine-induced conditioned place preference in mice. 29 Sep 2008
• Nitric oxide and peroxynitrite regulate transporter transcription in rat liver slices. 29 Sep 2008
• The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats. 10 Sep 2008

See a longer list of these articles.

Technical information about 'Molsidomine'

Definition: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.

Chemical name: Sydnone imine, N-(ethoxycarbonyl)-3-(4-morpholinyl)-

Registry Number: 25717-80-0

Descriptor UI: D008981

Alternative terms: Molsidomine; Morsydomine; Molsidomin; Corvaton; Korvatone; Molsidain; Aventis Brand of Molsidomine; Molsidomine Aventis Brand; duracoron; Merck dura Brand of Molsidomine; Fali-Cor; Fali Cor; Salutas Brand of Molsidomine; Molsidomine Salutas Brand; Molsi 1A Pharma; 1A Brand of Molsidomine; Molsidomine 1A Brand; Molsi-AZU; Molsi AZU; Azupharma Brand of Molsidomine; Molsidomine Azupharma Brand; Molsi-Puren; Molsi Puren; Alpharma Brand of Molsidomine; Molsidomine Alpharma Brand; Molsibeta; Molsicor; betapharm Brand of Molsidomine; Molsidomine betapharm Brand; Molsidomin Heumann; Heumann, Molsidomin; Heumann Brand of Molsidomine; Molsidomine Heumann Brand; Molsidomin Stada; Stadapharm Brand of Molsidomine; Molsidomine Stadapharm Brand; molsidomin von ct; ct-Arzneimittel Brand of Molsidomine; Molsidomine ct-Arzneimittel Brand; ct Arzneimittel Brand of Molsidomine; SIN-10; SIN 10; SIN10; Sydnopharm; Molsidomin-ratiopharm; Molsidomin ratiopharm; Molsidominratiopharm; ratiopharm Brand of Molsidomine; Molsidomine ratiopharm Brand; Molsihexal; Hexal Brand of Molsidomine; Molsidomine Hexal Brand; Molsiket; Schwarz Brand of Molsidomine; Molsidomine Schwarz Brand; Sanol Brand of Molsidomine; Molsidomine Sanol Brand; MTW-Molsidomin; MTW Molsidomin; MTW Brand of Molsidomine; Molsidomine MTW Brand; Corpea; Normon Brand of Molsidomine; Molsidomine Normon Brand;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vasodilator Agents; Nitric Oxide Donors;

Tree Number: D03.383.129.462.580.693.450; D03.383.533.640.362;

History Note: 87