Molsidomine
Research News and Information

Sunday, November 22, 2009

Inhibition of the soluble epoxide hydrolase by tyrosine nitration.

22 Aug 2009 Inhibition of the soluble epoxide hydrolase (sEH) has beneficial effects on vascular inflammation and hypertension indicating that the enzyme may be a promising target for drug development. As the enzymatic core of the hydrolase domain of the human ... Read more...

Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt.

10 Aug 2009 Accumulating evidence suggests that peroxynitrite (ONOO(-)) is involved in the pathogenesis of insulin resistance. In the current study, we investigated whether insulin resistance in vivo could be mediated by nitration of proteins involved in the ... Read more...

Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.

29 Jun 2009 Our aim was to determine whether a Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) can protect retinal ganglion cells (RGCs) against retinal damage in vitro and in ... Read more...

Latest indexed articles for 'Molsidomine'

These are the very latest articles for this heading:

• Inhibition of the soluble epoxide hydrolase by tyrosine nitration. 22 Aug 2009
• Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt. 10 Aug 2009
• Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. 29 Jun 2009
• Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage. 29 Jun 2009
• Examination of imprinting process with molsidomine as a template. 15 Jun 2009
• The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat. 6 Jun 2009
• Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage. 30 May 2009
• Peroxynitrite induces gene expression in intervertebral disc cells. 13 May 2009
• Sudden cardiac death in patients with silent myocardial ischemia after myocardial infarction (from the Swiss Interventional Study on Silent Ischemia Type II [SWISSI II]). 12 May 2009
• NOC-9, a selective nitric oxide donor, induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble guanylate cyclase. 5 May 2009
• PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major. 23 Apr 2009
• Nitric oxide- and cGMP-active compounds affect the discharge of substantia nigra pars reticulata neurons: in vivo evidences in the rat. 5 Apr 2009
• Cyclic guanosine monophosphate signaling cascade mediates pigment aggregation in freshwater shrimp chromatophores. 30 Mar 2009
• Nitric oxide donor-mediated inhibition of phosphorylation shows that light-mediated degradation of photosystem II D1 protein and phosphorylation are not tightly linked. 16 Mar 2009
• Full-face treatments with the 2790-nm erbium:YSGG laser system. 27 Feb 2009
• Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro. 24 Feb 2009
• SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium. 18 Feb 2009
• Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: a neurochemical study . 30 Jan 2009
• Cruciferous dithiolethione-mediated coordinated induction of total cellular and mitochondrial antioxidants and phase 2 enzymes in human primary cardiomyocytes: cytoprotection against oxidative/electrophilic stress and doxorubicin toxicity. 26 Jan 2009
• Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: Implications for the role of astrogliosis in amyotrophic lateral sclerosis. 13 Jan 2009

See a longer list of these articles.

Technical information about 'Molsidomine'

Definition: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.

Chemical name: Sydnone imine, N-(ethoxycarbonyl)-3-(4-morpholinyl)-

Registry Number: 25717-80-0

Descriptor UI: D008981

Alternative terms: Molsidomine; Morsydomine; Molsidomin; Corvaton; Korvatone; Molsidain; Aventis Brand of Molsidomine; Molsidomine Aventis Brand; duracoron; Merck dura Brand of Molsidomine; Fali-Cor; Fali Cor; Salutas Brand of Molsidomine; Molsidomine Salutas Brand; Molsi 1A Pharma; 1A Brand of Molsidomine; Molsidomine 1A Brand; Molsi-AZU; Molsi AZU; Azupharma Brand of Molsidomine; Molsidomine Azupharma Brand; Molsi-Puren; Molsi Puren; Alpharma Brand of Molsidomine; Molsidomine Alpharma Brand; Molsibeta; Molsicor; betapharm Brand of Molsidomine; Molsidomine betapharm Brand; Molsidomin Heumann; Heumann, Molsidomin; Heumann Brand of Molsidomine; Molsidomine Heumann Brand; Molsidomin Stada; Stadapharm Brand of Molsidomine; Molsidomine Stadapharm Brand; molsidomin von ct; ct-Arzneimittel Brand of Molsidomine; Molsidomine ct-Arzneimittel Brand; ct Arzneimittel Brand of Molsidomine; SIN-10; SIN 10; SIN10; Sydnopharm; Molsidomin-ratiopharm; Molsidomin ratiopharm; Molsidominratiopharm; ratiopharm Brand of Molsidomine; Molsidomine ratiopharm Brand; Molsihexal; Hexal Brand of Molsidomine; Molsidomine Hexal Brand; Molsiket; Schwarz Brand of Molsidomine; Molsidomine Schwarz Brand; Sanol Brand of Molsidomine; Molsidomine Sanol Brand; MTW-Molsidomin; MTW Molsidomin; MTW Brand of Molsidomine; Molsidomine MTW Brand; Corpea; Normon Brand of Molsidomine; Molsidomine Normon Brand;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vasodilator Agents; Nitric Oxide Donors;

Tree Number: D03.383.129.462.580.693.450; D03.383.533.640.362;

History Note: 87