Monoamine Oxidase - Genetics
Research News and Information

Monday, November 23, 2009

Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder.

30 Jul 2009 The placebo response shows pronounced interindividual variability. Placebos are postulated to act through central reward pathways that are modulated by monoamines. Because monoaminergic signaling is under strong genetic control, we hypothesized that ... Read more...

Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-A activity.

21 Jul 2009 The p38 mitogen-activated protein kinase (MAPK) cascade as well as the enzyme monoamine oxidase-A (MAO-A) have both been associated with oxidative stress. We observed that the specific inhibition of the p38(MAPK) protein [using either a chemical ... Read more...

Mutagenic probes of the role of Ser209 on the cavity shaping loop of human monoamine oxidase A.

21 Jul 2009 The available literature implicating human monoamine oxidase A (MAO A) in apoptotic processes reports levels of MAO A protein that do not correlate with activity, suggesting that unknown mechanisms may be involved in the regulation of catalytic ... Read more...

Latest indexed articles for 'Monoamine Oxidase - Genetics'

These are the very latest articles for this heading:

• Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. 30 Jul 2009
• Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-A activity. 21 Jul 2009
• Mutagenic probes of the role of Ser209 on the cavity shaping loop of human monoamine oxidase A. 21 Jul 2009
• The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. 17 Jul 2009
• [Development of serotonergic neurons of dorsal raphe nuclei in mice with knockout of monoamine oxidase A and 5-HT1A and 5-HT1B autoreceptor] 29 Jun 2009
• Monoamine oxidase a promoter gene associated with problem behavior in adults with intellectual/developmental disabilities. 29 Jun 2009
• Neural connectivity as an intermediate phenotype: brain networks under genetic control. 29 Jun 2009
• Membrane attachment facilitates ligand access to the active site in monoamine oxidase A. 28 Jun 2009
• Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. 17 Jun 2009
• Calcium alters monoamine oxidase-A parameters in human cerebellar and rat glial C6 cell extracts: possible influence by distinct signalling pathways. 15 Jun 2009
• Candidate gene studies of ADHD: a meta-analytic review. 7 Jun 2009
• Genetics of human aggressive behaviour. 7 Jun 2009
• Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder. Jun 2009
• MAOA gene polymorphisms and response to mirtazapine in major depression. 30 May 2009
• Neural mechanisms of anger regulation as a function of genetic risk for violence. 30 May 2009
• Parental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women. 30 May 2009
• Biosocial influences on fraudulent behaviors. 30 May 2009
• Molecular genetics of migraine. 18 May 2009
• Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. 29 Apr 2009
• Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. 26 Apr 2009

See a longer list of these articles.

Technical information about 'Monoamine Oxidase'

Definition: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.

Chemical name: Amine:oxygen oxidoreductase (deaminating) (flavin-containing)

Registry Number: EC 1.4.3.4

Descriptor UI: D008995

Alternative terms: Monoamine Oxidase; Oxidase, Monoamine; Amine Oxidase (Flavin-Containing); MAO; Tyramine Oxidase; Oxidase, Tyramine; Type A Monoamine Oxidase; MAO-A; MAO A; Monoamine Oxidase A; Monoamine Oxidase B; MAO-B; MAO B; Type B Monoamine Oxidase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.664.750;

History Note: 63; for TYRAMINE OXIDASE use MONOAMINE OXIDASE (NM) 1980-98