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Monoamine Oxidase
Research News and Information
Definition of 'Monoamine Oxidase'An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4. |
Sunday, November 22, 2009
Serotonin produces monoamine oxidase-dependent oxidative stress in human heart valves.
5 Aug 2009 
Heart valve disease and pulmonary hypertension, in patients with carcinoid tumors and people who used the fenfluramine-phentermine combination for weight control, have been associated with high levels of serotonin in blood. The mechanism by which ... Read more...
30 Jul 2009 Individual differences in a functional polymorphism of the promoter of the Monoamine oxidase A (MAO-A) gene might partly explain the increased vulnerability of maltreated children for externalizing behaviour. A sample of 239 internationally adopted ... Read more...
30 Jul 2009 Neuroprotective therapy has been proposed for age-related neurodegenerative disorders, including Parkinson's disease. Inhibitors of type B monoamine oxidase (MAOB-Is), rasagiline and (-)deprenyl, are the most promising candidate neuroprotective ... Read more...
Latest indexed articles for 'Monoamine Oxidase'
These are the very latest articles for this heading:
- Serotonin produces monoamine oxidase-dependent oxidative stress in human heart valves. 5 Aug 2009
- High activity of monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees. 30 Jul 2009
- Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease. 30 Jul 2009
- Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. 30 Jul 2009
- A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. 30 Jul 2009
- Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-A activity. 21 Jul 2009
- Mutagenic probes of the role of Ser209 on the cavity shaping loop of human monoamine oxidase A. 21 Jul 2009
- The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. 17 Jul 2009
- Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A. 13 Jul 2009
- Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer's disease. 10 Jul 2009
- [Development of serotonergic neurons of dorsal raphe nuclei in mice with knockout of monoamine oxidase A and 5-HT1A and 5-HT1B autoreceptor] 29 Jun 2009
- Monoamine oxidase a promoter gene associated with problem behavior in adults with intellectual/developmental disabilities. 29 Jun 2009
- Neural connectivity as an intermediate phenotype: brain networks under genetic control. 29 Jun 2009
- Membrane attachment facilitates ligand access to the active site in monoamine oxidase A. 28 Jun 2009
- Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. 17 Jun 2009
- Calcium alters monoamine oxidase-A parameters in human cerebellar and rat glial C6 cell extracts: possible influence by distinct signalling pathways. 15 Jun 2009
- Candidate gene studies of ADHD: a meta-analytic review. 7 Jun 2009
- Genetics of human aggressive behaviour. 7 Jun 2009
- Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain. 5 Jun 2009
- Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder. Jun 2009
See a longer list of these articles.
Technical information about 'Monoamine Oxidase'
Definition: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Chemical name: Amine:oxygen oxidoreductase (deaminating) (flavin-containing)
Registry Number: EC 1.4.3.4
Descriptor UI: D008995
Alternative terms: Monoamine Oxidase; Oxidase, Monoamine; Amine Oxidase (Flavin-Containing); MAO; Tyramine Oxidase; Oxidase, Tyramine; Type A Monoamine Oxidase; MAO-A; MAO A; Monoamine Oxidase A; Monoamine Oxidase B; MAO-B; MAO B; Type B Monoamine Oxidase;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;
Tree Number: D08.811.682.664.750;
History Note: 63; for TYRAMINE OXIDASE use MONOAMINE OXIDASE (NM) 1980-98