Morphine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.

30 Oct 2009 BACKGROUND: Methadone is an opioid agonist often given to manage acute and chronic pain. We sought to determine whether methadone compared with morphine dose dependently reduces myocardial infarct size (IS) and whether the mechanism is delta-opioid ... Read more...

T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

19 Oct 2009 Lipoamino acids are anandamide-related endogenous molecules that induce analgesia via unresolved mechanisms. Here, we provide evidence that the T-type/Cav3 calcium channels are important pharmacological targets underlying their physiological ... Read more...

Nuclear expression of mu-opioid receptors in a human mesothelial cell line.

29 Sep 2009 1 Possibly acting via mu-opioid receptors (MORs), morphine inhibits the formation of experimentally induced postoperative abdominal adhesions in rats. Mesothelial cells may participate in adhesion formation by secreting mediators that interfere ... Read more...

Latest indexed articles for 'Morphine - Pharmacology'

These are the very latest articles for this heading:

• Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion. 30 Oct 2009
• T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. 19 Oct 2009
• Nuclear expression of mu-opioid receptors in a human mesothelial cell line. 29 Sep 2009
• Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrozole. 29 Sep 2009
• Regulation of kinesin light chain 1 level correlates with the development of morphine reward in the mouse brain. 2 Sep 2009
• Revisiting tolerance from the endogenous morphine perspective. 30 Aug 2009
• Effects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats. 30 Aug 2009
• Central administration of minocycline and riluzole prevents morphine-induced tolerance in rats. 30 Aug 2009
• Involvement of nitric oxide synthesis in sensitization to the rewarding effects of morphine. 9 Aug 2009
• Unnecessary medicines? 30 Jul 2009
• Examination of reinforcement magnitude on the pharmacological disruption of fixed-ratio performance. 30 Jul 2009
• Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice. 30 Jul 2009
• CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system. 22 Jul 2009
• Morphine-induced suppression of conditioned stimulus intake: effects of stimulus type and insular cortex lesions. 21 Jul 2009
• Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica. 20 Jul 2009
• Suppressive effects of lamotrigine on the development and expression of tolerance to morphine-induced antinociception in the male mouse. 13 Jul 2009
• Role for GABA agonists in the nucleus accumbens in regulating morphine self-administration. 8 Jul 2009
• Memantine blocks sensitization to the rewarding effects of morphine. 7 Jul 2009
• Evidence for opioid-induced release of glutamate in guinea pig longitudinal muscle-myenteric plexus strip. 30 Jun 2009
• Prevention and reversal of morphine tolerance by the analgesic neuroactive steroid alphadolone. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Morphine'

Definition: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Chemical name: Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-

Registry Number: 57-27-2

Descriptor UI: D009020

Alternative terms: Morphine; Morphia; Morphine Chloride; Chloride, Morphine; Morphine Sulfate; Sulfate, Morphine; SDZ 202-250; SDZ 202 250; SDZ 202250; SDZ202-250; SDZ202 250; SDZ202250; Morphine Sulfate (2:1), Pentahydrate; MS Contin; Contin, MS; Oramorph SR; Duramorph; Morphine Sulfate (2:1), Anhydrous;

Related Mesh Headings: Receptors, Opioid;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis;

Pharmacological Action: Analgesics, Opioid; Narcotics;

Tree Number: D03.132.577.249.547; D03.549.686.575; D03.605.497.575; D04.615.723.795.547;

History Note: MORPHINE SULFATE was (NM) 1980-96

Technical Notes: /analogs = MORPHINE DERIVATIVES