Morphine Derivatives - Pharmacology
Research News and Information

Monday, November 23, 2009

Increased locomotor activity induced by heroin in mice: pharmacokinetic demonstration of heroin acting as a prodrug for the mediator 6-monoacetylmorphine in vivo.

16 Jun 2009 We investigated the relative importance of heroin and its metabolites in eliciting a behavioral response in mice by studying the relationship between concentrations of heroin, 6-monoacetylmorphine (6MAM), and morphine in brain tissue and the effects ... Read more...

Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans.

30 May 2009 BACKGROUND: Previous data indicate that morphine-6beta-glucuronide (M6G), a morphine metabolite with analgesic properties, can paradoxically increase pain sensitivity in mice and humans. The authors tested mice and humans for M6G hyperalgesia and ... Read more...

Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive.

12 May 2009 A synthetic mannoside derivative, namely, 6-morphinyl-alpha-D-mannopyranoside, shows a naloxone-reversible antinociception that is 100-fold more potent and twice as long lasting compared to morphine when administered intraperitoneally to rats in paw ... Read more...

Latest indexed articles for 'Morphine Derivatives - Pharmacology'

These are the very latest articles for this heading:

• Increased locomotor activity induced by heroin in mice: pharmacokinetic demonstration of heroin acting as a prodrug for the mediator 6-monoacetylmorphine in vivo. 16 Jun 2009
• Pleiotropic effects of morphine-6beta-glucuronide. 30 May 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive. 12 May 2009
• Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions. 3 Apr 2009
• Synthesis of novel twin drug consisting of 8-oxaendoethanotetrahydromorphides with a 1,4-dioxane spacer and its pharmacological activities: mu, kappa, and putative epsilon opioid receptor antagonists. 16 Nov 2008
• Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice. 8 Oct 2008
• Differential effect of morphine and morphine-6-glucuronide on the control of breathing in the anesthetized cat. 29 Sep 2008
• Behavioural sensitization in mice induced by morphine-glucuronide metabolites. 29 Sep 2008
• Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation. 28 Aug 2008
• Morphine-6-glucuronide, an active morphine metabolite for the potential treatment of post-operative pain. 29 Jun 2008
• The release and analgesic activities of morphine and its ester prodrug, morphine propionate, formulated by water-in-oil nanoemulsions. 29 Apr 2008
• The chemical and pharmacological importance of morphine analogues. 28 Feb 2008
• Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. 25 Feb 2008
• Different time schedules affect conditioned place preference after morphine and morphine-6-glucuronide administration. 24 Jan 2008
• [Antitussives and expectorants] 30 Dec 2007
• Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2. 6 Feb 2007
• Different effects of morphine and morphine-6beta-glucuronide on formalin-evoked spinal glutamate release in conscious and freely moving rats. 8 Jan 2007
• Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human micro-opioid receptors (hMORs) containing the A118G single-nucleotide polymorphism. 4 Dec 2006
• Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring. 3 Oct 2006

See a longer list of these articles.

Technical information about 'Morphine Derivatives'

Definition: Analogs or derivatives of morphine.

Registry Number: 0

Descriptor UI: D009022

Alternative terms: Morphine Derivatives; Derivatives, Morphine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.132.577.249.547.547; D03.549.686.575.547; D03.605.497.575.547; D04.615.723.795.547.547;

Online Note: search MORPHINANS 1969-74

History Note: 78(75); was see under MORPHINE 1975-77, was see under MORPHINANS 1969-74