Morphine Derivatives
Research News and Information

Sunday, November 22, 2009

Effect of acute inflammatory brain injury on accumulation of morphine and morphine 3- and 6-glucuronide in the human brain.

29 Sep 2009 OBJECTIVE: In animals, central nervous system inflammation increases drug accumulation in the brain partly due to a loss of central nervous system drug efflux transporter function at the blood-brain barrier. To determine whether a similar loss of ... Read more...

Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis.

30 Aug 2009 OBJECTIVES: The aim was to investigate the disposition of morphine and morphine-3-glucuronide (M3G) in a rat model of cholestasis induced by bile duct ligation (BDL). METHODS: Morphine (15 mg/kg) was administered intravenously, and morphine and M3G ... Read more...

Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.

5 Jul 2009 Intrathecal (i.t.) injection of morphine-3-glucuronide (M3G), a major metabolite of morphine without analgesic actions, produces a severe hindlimb scratching followed by biting and licking in mice. The pain-related behavior evoked by M3G was ... Read more...

Latest indexed articles for 'Morphine Derivatives'

These are the very latest articles for this heading:

• No brain, no pain: does the injured brain stack up opioids? 29 Sep 2009
• Effect of acute inflammatory brain injury on accumulation of morphine and morphine 3- and 6-glucuronide in the human brain. 29 Sep 2009
• Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis. 30 Aug 2009
• Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide. 5 Jul 2009
• Simultaneous analysis of morphine-related compounds in plasma using mixed-mode solid phase extraction and UltraPerformance liquid chromatography-mass spectrometry. 29 Jun 2009
• Characterization of human and bovine phosphatidylethanolamine-binding protein (PEBP/RKIP) interactions with morphine and morphine-glucuronides determined by noncovalent mass spectrometry. 29 Jun 2009
• Increased locomotor activity induced by heroin in mice: pharmacokinetic demonstration of heroin acting as a prodrug for the mediator 6-monoacetylmorphine in vivo. 16 Jun 2009
• Simultaneous quantification of methadone, cocaine, opiates, and metabolites in human placenta by liquid chromatography-mass spectrometry. 30 May 2009
• Pleiotropic effects of morphine-6beta-glucuronide. 30 May 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive. 12 May 2009
• Optimization of a rapid microwave-assisted extraction method for the simultaneous determination of opiates, cocaine and their metabolites in human hair. May 2009
• Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions. 3 Apr 2009
• Interactions between morphine and the morphine-glucuronides measured by conditioned place preference and locomotor activity. 3 Apr 2009
• The use of CE ECL with ionic liquid for the determination of drug alkaloids and applications in human urine. 30 Mar 2009
• Pharmacokinetic and pharmacodynamic study of morphine and morphine 6-glucuronide after oral and intravenous administration of morphine in children with cancer. 30 Mar 2009
• Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/electrospray ionization tandem mass spectrometry. 30 Mar 2009
• Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents. 25 Mar 2009
• A validated hybrid quadrupole linear ion-trap LC-MS method for the analysis of morphine and morphine glucuronides applied to opiate deaths. 15 Mar 2009
• On the origin and specificity of antibodies to neuromuscular blocking (muscle relaxant) drugs: an immunochemical perspective. 27 Feb 2009

See a longer list of these articles.

Technical information about 'Morphine Derivatives'

Definition: Analogs or derivatives of morphine.

Registry Number: 0

Descriptor UI: D009022

Alternative terms: Morphine Derivatives; Derivatives, Morphine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.132.577.249.547.547; D03.549.686.575.547; D03.605.497.575.547; D04.615.723.795.547.547;

Online Note: search MORPHINANS 1969-74

History Note: 78(75); was see under MORPHINE 1975-77, was see under MORPHINANS 1969-74