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Multiple Sclerosis - Pathology
Research News and Information
Definition of 'Multiple Sclerosis'An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) |
Monday, November 23, 2009
Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study.
Nov 2009 
BACKGROUND: Interferon beta (IFNbeta) administered subcutaneously is immunogenic in some patients with multiple sclerosis (MS) and leads to the development of neutralizing antibodies (NAbs). Considerable evidence has accumulated that NAbs diminish ... Read more...
30 Oct 2009 Preclinical investigations utilizing murine experimental auto-immune encephalomyelitis (EAE), as well as clinical observations in patients with multiple sclerosis (MS), may suggest alteration of endogenous opioid systems in MS. In this study we used ... Read more...
Potential roles of cell-derived microparticles in ischemic brain disease.
29 Sep 2009 PURPOSE: The objective of this study is to review the role of cell-derived microparticles in ischemic cerebrovascular diseases. MATERIALS AND METHODS: An extensive PubMed search of literature pertaining to this study was performed in April 2009 ... Read more...
Latest indexed articles for 'Multiple Sclerosis - Pathology'
These are the very latest articles for this heading:
- Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study. Nov 2009
- Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis. 30 Oct 2009
- Humoral pattern II multiple sclerosis pathology not associated with neuromyelitis Optica IgG.
29 Sep 2009 - Potential roles of cell-derived microparticles in ischemic brain disease. 29 Sep 2009
- Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months. 20 Sep 2009
- Interferon-beta therapy for multiple sclerosis--is the injection site the relevant action site? 18 Sep 2009
- Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis. 13 Sep 2009
- Progressive multifocal leukoencephalopathy after natalizumab monotherapy. 8 Sep 2009
- Treatment of progressive multifocal leukoencephalopathy associated with natalizumab. 8 Sep 2009
- Spatial diversity of blood-brain barrier alteration and macrophage invasion in experimental autoimmune encephalomyelitis: a comparative MRI study. 2 Sep 2009
- Antigen-specific therapies in multiple sclerosis. 30 Aug 2009
- Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients? 30 Aug 2009
- A comparison of 3T and 7T in the detection of small parenchymal veins within MS lesions. 30 Aug 2009
- "Cloud-like enhancement" is a magnetic resonance imaging abnormality specific to neuromyelitis optica. 30 Aug 2009
- Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. 30 Aug 2009
- Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis. 30 Aug 2009
- Multiple sclerosis with predominant, severe cognitive impairment. 30 Aug 2009
- Texture analysis of magnetization transfer maps from patients with clinically isolated syndrome and multiple sclerosis. 30 Aug 2009
- Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis. 30 Aug 2009
- Diffusion-weighted imaging: not all that glitters is gold. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Multiple Sclerosis'
Definition: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Descriptor UI: D009103
Alternative terms: Multiple Sclerosis; Sclerosis, Multiple; Sclerosis, Disseminated; Disseminated Sclerosis; MS (Multiple Sclerosis); Multiple Sclerosis, Acute Fulminating;
Related Mesh Headings: Myelitis, Transverse;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C10.114.375.500; C10.314.350.500; C20.111.258.250.500;