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Multiple Sclerosis - Physiopathology
Research News and Information
Definition of 'Multiple Sclerosis'An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) |
Monday, November 23, 2009
Resistance training improves muscle strength and functional capacity in multiple sclerosis.
Nov 2009 
OBJECTIVE: To test the hypothesis that lower extremity progressive resistance training (PRT) can improve muscle strength and functional capacity in patients with multiple sclerosis (MS) and to evaluate whether the improvements are maintained after ... Read more...
30 Oct 2009 OBJECTIVE: To make a preliminary evaluation of the feasibility of a robot-based rehabilitation protocol for the improvement of upper limb motor co-ordination in a group of patients with multiple sclerosis. PATIENTS AND METHODS: Seven patients with ... Read more...
Innate and adaptive autoimmunity directed to the central nervous system.
13 Oct 2009 The immune system has two major components, an innate arm and an adaptive arm. Certain autoimmune diseases of the brain represent examples of disorders where one of these constituents plays a major role. Some rare autoimmune diseases involve ... Read more...
Latest indexed articles for 'Multiple Sclerosis - Physiopathology'
These are the very latest articles for this heading:
- Resistance training improves muscle strength and functional capacity in multiple sclerosis. Nov 2009
- Robot-based rehabilitation of the upper limbs in multiple sclerosis: feasibility and preliminary results. 30 Oct 2009
- Innate and adaptive autoimmunity directed to the central nervous system. 13 Oct 2009
- Calibration of accelerometer output for ambulatory adults with multiple sclerosis. 29 Sep 2009
- Potential roles of cell-derived microparticles in ischemic brain disease. 29 Sep 2009
- Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months. 20 Sep 2009
- Using fast eye movements to study fatigue in multiple sclerosis. 6 Sep 2009
- Spatial diversity of blood-brain barrier alteration and macrophage invasion in experimental autoimmune encephalomyelitis: a comparative MRI study. 2 Sep 2009
- Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients? 30 Aug 2009
- Multiple sclerosis: change in health-related quality of life over two years. 30 Aug 2009
- Health-related quality of life in MS: issues and interventions.
30 Aug 2009 - Propagation of spreading depression inversely correlates with cortical myelin content. 30 Aug 2009
- Addressing the need for increased adherence to multiple sclerosis therapy: can delivery technology enhance patient motivation? 30 Aug 2009
- Physical and cognitive functioning after 3 years can be predicted using information from the diagnostic process in recently diagnosed multiple sclerosis. 30 Aug 2009
- Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis. 30 Aug 2009
- What you see depends on how you look: Gray matter lesions in multiple sclerosis. 17 Aug 2009
- Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis. 16 Aug 2009
- Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. 13 Aug 2009
- Endothelial NOS-deficient mice reveal dual roles for nitric oxide during experimental autoimmune encephalomyelitis. 13 Aug 2009
- [Plasticity of the motor system in multiple sclerosis] 12 Aug 2009
See a longer list of these articles.
Technical information about 'Multiple Sclerosis'
Definition: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Descriptor UI: D009103
Alternative terms: Multiple Sclerosis; Sclerosis, Multiple; Sclerosis, Disseminated; Disseminated Sclerosis; MS (Multiple Sclerosis); Multiple Sclerosis, Acute Fulminating;
Related Mesh Headings: Myelitis, Transverse;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C10.114.375.500; C10.314.350.500; C20.111.258.250.500;