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Multiple Sclerosis
Research News and Information
Definition of 'Multiple Sclerosis'An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) |
Sunday, November 22, 2009
Effect of neutralizing antibodies on biomarker responses to interferon beta: the INSIGHT study.
Nov 2009 
BACKGROUND: Interferon beta (IFNbeta) effectively reduces disease activity in patients with multiple sclerosis (MS). Neutralizing antibodies (NAbs) can diminish or abolish the clinical efficacy of IFNbeta therapies. Biomarkers of the IFNbeta ... Read more...
Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study.
Nov 2009 BACKGROUND: Interferon beta (IFNbeta) administered subcutaneously is immunogenic in some patients with multiple sclerosis (MS) and leads to the development of neutralizing antibodies (NAbs). Considerable evidence has accumulated that NAbs diminish ... Read more...
Resistance training improves muscle strength and functional capacity in multiple sclerosis.
Nov 2009 OBJECTIVE: To test the hypothesis that lower extremity progressive resistance training (PRT) can improve muscle strength and functional capacity in patients with multiple sclerosis (MS) and to evaluate whether the improvements are maintained after ... Read more...
Latest indexed articles for 'Multiple Sclerosis'
These are the very latest articles for this heading:
- Effect of neutralizing antibodies on biomarker responses to interferon beta: the INSIGHT study. Nov 2009
- Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study. Nov 2009
- Resistance training improves muscle strength and functional capacity in multiple sclerosis. Nov 2009
- Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis. 30 Oct 2009
- Robot-based rehabilitation of the upper limbs in multiple sclerosis: feasibility and preliminary results. 30 Oct 2009
- Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report. 21 Oct 2009
- Innate and adaptive autoimmunity directed to the central nervous system. 13 Oct 2009
- Gray-matter injury in multiple sclerosis.
6 Oct 2009 - Gamma knife radiosurgery for multiple sclerosis-related trigeminal neuralgia. 4 Oct 2009
- [Fingolimod - a new immunomodulator] 4 Oct 2009
- Humoral pattern II multiple sclerosis pathology not associated with neuromyelitis Optica IgG. 29 Sep 2009
- Immunotherapy for multiple sclerosis: the curious case of interferon beta. 29 Sep 2009
- Calibration of accelerometer output for ambulatory adults with multiple sclerosis. 29 Sep 2009
- Interferon beta retinopathy in a patient with multiple sclerosis. 29 Sep 2009
- Potential roles of cell-derived microparticles in ischemic brain disease. 29 Sep 2009
- Costimulatory pathways in multiple sclerosis: distinctive expression of PD-1 and PD-L1 in patients with different patterns of disease. 28 Sep 2009
- IFN-beta inhibits human Th17 cell differentiation. 23 Sep 2009
- [Myofacial or neuropathic pain? Differential diagnosis with relatively little investment] 22 Sep 2009
- Severe cardiac failure in a patient with multiple sclerosis following low-dose mitoxantrone treatment. 20 Sep 2009
- The present efficacy of multiple sclerosis therapeutics: Is the new 66% just the old 33%? 20 Sep 2009
See a longer list of these articles.
Technical information about 'Multiple Sclerosis'
Definition: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Descriptor UI: D009103
Alternative terms: Multiple Sclerosis; Sclerosis, Multiple; Sclerosis, Disseminated; Disseminated Sclerosis; MS (Multiple Sclerosis); Multiple Sclerosis, Acute Fulminating;
Related Mesh Headings: Myelitis, Transverse;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C10.114.375.500; C10.314.350.500; C20.111.258.250.500;