Muscimol - Pharmacology
Research News and Information

Saturday, November 21, 2009

Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons.

30 Oct 2009 Rundown is ubiquitously seen in response to repetitive activation of receptor or ion channels as a use-dependent down-regulation through various mechanisms. In contrast to AMPA receptors, gamma-aminobutyric acid type A receptor (GABA(A)R) are ... Read more...

Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC.

29 Sep 2009 Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: ... Read more...

Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction.

23 Aug 2009 Rats were subjected to one or two cycles of context fear conditioning and extinction to study the roles of the prelimbic cortex (PL) and infralimbic cortex (IL) in learning and relearning to inhibit fear responses. Inactivation of the PL depressed ... Read more...

Latest indexed articles for 'Muscimol - Pharmacology'

These are the very latest articles for this heading:

• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons. 30 Oct 2009
• Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC. 29 Sep 2009
• Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction. 23 Aug 2009
• Hibernation induces pentobarbital insensitivity in medulla but not cortex. 10 Aug 2009
• The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning. 30 Jul 2009
• Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior. 30 Jul 2009
• Temporary inactivation of ventral tegmental area neurons with either muscimol or baclofen reversibly disrupts maternal behavior in rats through different underlying mechanisms. 30 Jul 2009
• Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. 30 Jul 2009
• Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. 30 Jul 2009
• Role for GABA agonists in the nucleus accumbens in regulating morphine self-administration. 8 Jul 2009
• GABAergic antagonism of the central nucleus of the amygdala attenuates reductions in rapid eye movement sleep after inescapable footshock stress. 29 Jun 2009
• Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. 29 Jun 2009
• Functional significance of nonspatial information in monkey lateral intraparietal area. 22 Jun 2009
• Memory and decision making in the frontal cortex during visual motion processing for smooth pursuit eye movements. 9 Jun 2009
• Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. 4 Jun 2009
• The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory. Jun 2009
• Pharmacological characterization of harmaline-induced tremor activity in mice. 31 May 2009
• Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats. 26 May 2009
• Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. 18 May 2009
• The anterior cingulate cortex is involved in retrieval of long-term/long-lasting but not short-term memory for step-through inhibitory avoidance in rats. 16 May 2009

See a longer list of these articles.

Technical information about 'Muscimol'

Definition: Neurotoxic isoxazole isolated from Amanita muscaria and A. phalloides and also obtained by decarboxylation of IBOTENIC ACID. It is a potent agonist at GABA-A receptors and is used mainly as an experimental tool in animal and tissue studies.

Chemical name: 3(2H)-Isoxazolone, 5-(aminomethyl)-

Registry Number: 2763-96-4

Descriptor UI: D009118

Alternative terms: Muscimol; Pantherine; Agarin;

Related Mesh Headings: Receptors, GABA-A;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: GABA Agonists;

Tree Number: D03.383.129.462.470; D23.946.587.587;

History Note: 86(79); was see under OXAZOLES 1979-85