Muscimol
Research News and Information

Saturday, November 21, 2009

Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons.

30 Oct 2009 Rundown is ubiquitously seen in response to repetitive activation of receptor or ion channels as a use-dependent down-regulation through various mechanisms. In contrast to AMPA receptors, gamma-aminobutyric acid type A receptor (GABA(A)R) are ... Read more...

Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC.

29 Sep 2009 Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: ... Read more...

The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice.

14 Sep 2009 Granulocyte-colony stimulating factor (G-CSF) is a hematopoietic growth factor that controls proliferation and differentiation of neural stem cells. Although recent studies have begun to explore G-CSF-related mechanisms of action in various disease ... Read more...

Latest indexed articles for 'Muscimol'

These are the very latest articles for this heading:

• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons. 30 Oct 2009
• Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC. 29 Sep 2009
• The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. 14 Sep 2009
• Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats. 9 Sep 2009
• Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction. 23 Aug 2009
• Hibernation induces pentobarbital insensitivity in medulla but not cortex. 10 Aug 2009
• The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning. 30 Jul 2009
• Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior. 30 Jul 2009
• Temporary inactivation of ventral tegmental area neurons with either muscimol or baclofen reversibly disrupts maternal behavior in rats through different underlying mechanisms. 30 Jul 2009
• Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. 30 Jul 2009
• Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. 30 Jul 2009
• Role for GABA agonists in the nucleus accumbens in regulating morphine self-administration. 8 Jul 2009
• GABAergic antagonism of the central nucleus of the amygdala attenuates reductions in rapid eye movement sleep after inescapable footshock stress. 29 Jun 2009
• Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. 29 Jun 2009
• Functional significance of nonspatial information in monkey lateral intraparietal area. 22 Jun 2009
• Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys. 13 Jun 2009
• Memory and decision making in the frontal cortex during visual motion processing for smooth pursuit eye movements. 9 Jun 2009
• Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. 4 Jun 2009
• The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory. Jun 2009
• Pharmacological characterization of harmaline-induced tremor activity in mice. 31 May 2009

See a longer list of these articles.

Technical information about 'Muscimol'

Definition: Neurotoxic isoxazole isolated from Amanita muscaria and A. phalloides and also obtained by decarboxylation of IBOTENIC ACID. It is a potent agonist at GABA-A receptors and is used mainly as an experimental tool in animal and tissue studies.

Chemical name: 3(2H)-Isoxazolone, 5-(aminomethyl)-

Registry Number: 2763-96-4

Descriptor UI: D009118

Alternative terms: Muscimol; Pantherine; Agarin;

Related Mesh Headings: Receptors, GABA-A;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: GABA Agonists;

Tree Number: D03.383.129.462.470; D23.946.587.587;

History Note: 86(79); was see under OXAZOLES 1979-85