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Mutagenesis, Insertional
Research News and Information
Definition of 'Mutagenesis, Insertional'Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation. |
Sunday, November 22, 2009
KAIKObase: an integrated silkworm genome database and data mining tool.
19 Oct 2009 
BACKGROUND: The silkworm, Bombyx mori, is one of the most economically important insects in many developing countries owing to its large-scale cultivation for silk production. With the development of genomic and biotechnological tools, B. mori has ... Read more...
Regulation of phenylacetic acid degradation genes of Burkholderia cenocepacia K56-2.
16 Oct 2009 BACKGROUND: Metabolically versatile soil bacteria Burkholderia cepacia complex (Bcc) have emerged as opportunistic pathogens, especially of cystic fibrosis (CF). Previously, we initiated the characterization of the phenylacetic acid (PA) degradation ... Read more...
JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche.
30 Sep 2009 Adult stem cells often reside in local microenvironments, or niches. Although niches can contain multiple types of stem cells, the coordinate regulation of stem cell behavior is poorly understood. In the Drosophila testis, Janus kinase-signal ... Read more...
Latest indexed articles for 'Mutagenesis, Insertional'
These are the very latest articles for this heading:
- KAIKObase: an integrated silkworm genome database and data mining tool. 19 Oct 2009
- Regulation of phenylacetic acid degradation genes of Burkholderia cenocepacia K56-2. 16 Oct 2009
- JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche. 30 Sep 2009
- Disruption of the pollen-expressed FERONIA homologs ANXUR1 and ANXUR2 triggers pollen tube discharge. 29 Sep 2009
- A combination of transposable elements and magnetic cell sorting provides a very efficient transgenesis system for chicken primary erythroid progenitors. 16 Sep 2009
- Specific osmolyte transporters mediate bile tolerance in Listeria monocytogenes. 6 Sep 2009
- Genome-wide analysis of Tol2 transposon reintegration in zebrafish. 6 Sep 2009
- Selective epigenetic control of retrotransposition in Arabidopsis. 4 Sep 2009
- Bursts of retrotransposition reproduced in Arabidopsis. 4 Sep 2009
- Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung. 2 Sep 2009
- An efficient and reversible transposable system for gene delivery and lineage-specific differentiation in human embryonic stem cells. 2 Sep 2009
- Outer membrane porin M35 of Moraxella catarrhalis mediates susceptibility to aminopenicillins. 2 Sep 2009
- The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens. 30 Aug 2009
- [Identification and genetic analysis of pale-green mutant caused by Ds insertion in rice] 30 Aug 2009
- [Mutation in the cspH-cspG gene cluster enhances expression of heat-shock proteins and SOS repair system of Escherichia coli] 30 Aug 2009
- Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB. 30 Aug 2009
- OsEF3, a homologous gene of Arabidopsis ELF3, has pleiotropic effects in rice. 30 Aug 2009
- A novel triple-regulated oncolytic adenovirus carrying PDCD5 gene exerts potent antitumor efficacy on common human leukemic cell lines. 30 Aug 2009
- Cost-effectiveness of ACE inhibitor therapy to prevent dialysis in nondiabetic nephropathy: influence of the ACE insertion/deletion polymorphism. 30 Aug 2009
- Growing Bacillus subtilis tendrils sense and avoid each other. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Mutagenesis, Insertional'
Definition: Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Descriptor UI: D016254
Alternative terms: Mutagenesis, Insertional; Insertional Mutagenesis; Sequence Insertion; Insertion, Sequence; Insertions, Sequence; Sequence Insertions; Viral Insertional Mutagenesis; Insertional Mutagenesis, Viral; Mutagenesis, Viral Insertional; Linker-Insertion Mutagenesis; Linker Insertion Mutagenesis; Mutagenesis, Linker-Insertion; Gene Insertion; Gene Insertions; Insertion, Gene; Insertions, Gene; Insertion Mutation; Insertion Mutations; Mutation, Insertion; Mutations, Insertion; Insertional Activation; Activation, Insertional; Activations, Insertional; Insertional Activations; Mutagenesis, Cassette; Cassette Mutagenesis;
Related Mesh Headings: DNA Transposable Elements;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; economics; history; instrumentation; methods; statistics & numerical data; standards; utilization;
Tree Number: E05.393.420.601.550; G05.355.600.550; G05.365.590.575;
History Note: 91