Myocardial Reperfusion Injury - Drug therapy
Research News and Information

Sunday, November 22, 2009

Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.

16 Sep 2009 We tested the effect of the antianginal agent ranolazine on ventricular arrhythmias in an ischemic model using two protocols. In protocol 1, anesthetized rats received either vehicle or ranolazine (10 mg/kg, iv bolus) and were subjected to 5 min of ... Read more...

Enhancement of amlodipine cardioprotection by quercetin in ischaemia/reperfusion injury in rats.

30 Aug 2009 OBJECTIVES: To investigate the possible modification of the cardioprotective effect of amlodipine when co-administered with quercetin in myocardial ischaemia/reperfusion-induced functional, metabolic and cellular alterations in rats. METHODS: Oral ... Read more...

GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.

30 Aug 2009 The antiarrhythmic dipeptide, GAP-134, ([2S,4R]-1[2-aminoacetyl]-4-benzamido-pyrrolidine-2-carboxylic acid) was evaluated in canine ischemia/reperfusion model. In dogs subjected to 60-minute ischemia and 4-hour reperfusion, GAP-134 was administered ... Read more...

Latest indexed articles for 'Myocardial Reperfusion Injury - Drug therapy'

These are the very latest articles for this heading:

• Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion. 16 Sep 2009
• Enhancement of amlodipine cardioprotection by quercetin in ischaemia/reperfusion injury in rats. 30 Aug 2009
• GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. 30 Aug 2009
• Emerging role of nitrite in myocardial protection. 27 Aug 2009
• NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics. 27 Aug 2009
• Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury. 8 Aug 2009
• Cardioprotective effect of sasanquasaponin preconditioning via bradykinin-NO pathway in isolated rat heart. 30 Jul 2009
• Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin. Jul 2009
• Treating myocardial stunning randomly, with either propofol or isoflurane following transient coronary occlusion and reperfusion in pigs. 29 Jun 2009
• Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. 21 Jun 2009
• The cardioprotective and inotropic components of the postconditioning effects of GLP-1 and GLP-1(9-36)a in an isolated rat heart. 16 Jun 2009
• Molecular mechanism underlying Akt activation in zinc-induced cardioprotection. 10 Jun 2009
• Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes. 9 Jun 2009
• Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion. 30 May 2009
• Potential role of Borreria hispida in ameliorating cardiovascular risk factors. 30 May 2009
• The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-kinase signaling pathway. 27 May 2009
• [Effects of tongxinluo on mini-swine vascular endothelial integrity and myocardial no-reflow in early reperfusion of acute myocardial infarction] 24 May 2009
• (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of phosphatidylinositol 3-kinase/Akt signaling and anti-inflammatory action in vivo. 18 May 2009
• The emergence of nitroxyl (HNO) as a pharmacological agent. 4 May 2009
• Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo. May 2009

See a longer list of these articles.

Technical information about 'Myocardial Reperfusion Injury'

Definition: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.

Descriptor UI: D015428

Alternative terms: Myocardial Reperfusion Injury; Injuries, Myocardial Reperfusion; Myocardial Reperfusion Injuries; Reperfusion Injuries, Myocardial; Reperfusion Injury, Myocardial; Injury, Myocardial Reperfusion; Myocardial Ischemic Reperfusion Injury;

Related Mesh Headings: Myocardial Reperfusion; Myocardial Stunning;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C14.280.238.615; C14.280.647.625; C14.907.585.625; C14.907.725.600; C23.550.767.877.500;

History Note: 89