N-Methyl-3,4-methylenedioxyamphetamine - Toxicity
Research News and Information

Sunday, November 22, 2009

Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.

29 Jun 2009 The delta opioid system is involved in the behavioral effects of various drugs of abuse. However, only a few studies have focused on the possible interactions between the opioid system and the effects of 3,4-methylenedioxymethamphetamine (MDMA). In ... Read more...

Pharmacodynamic characterization of insulin on MDMA-induced thermogenesis.

27 May 2009 Sympathomimetic drugs (MDMA; ecstasy) induce a potentially catastrophic hyperthermia that involves free fatty acid (FFA) activation of mitochondrial uncoupling proteins (UCP). Insulin is an important regulator of plasma FFA levels, although its role ... Read more...

(+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty.

15 Apr 2009 During postnatal days (PD) 11-20, (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment impairs egocentric and allocentric learning, and reduces spontaneous locomotor activity; however, it does not have these effects during PD 1-10. How the ... Read more...

Latest indexed articles for 'N-Methyl-3,4-methylenedioxyamphetamine - Toxicity'

These are the very latest articles for this heading:

• Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice. 29 Jun 2009
• Pharmacodynamic characterization of insulin on MDMA-induced thermogenesis. 27 May 2009
• [Ecstasy, new psychotropic drugs] 29 Apr 2009
• (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty. 15 Apr 2009
• Dissociation between serotonin neurotoxicity and brain-derived neurotrophic factor induction following neonatal MDMA exposure in rats. 15 Apr 2009
• Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy"). 3 Apr 2009
• Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes. 29 Mar 2009
• Transcriptomic configuration of mouse brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine. 8 Mar 2009
• Prior MDMA (Ecstasy) use is associated with increased basal ganglia-thalamocortical circuit activation during motor task performance in humans: an fMRI study. 28 Feb 2009
• Importance of psychiatric confounding in non-randomized studies of heavy ecstasy users. 10 Feb 2009
• Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat. 30 Jan 2009
• Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines. 30 Dec 2008
• The harmful health effects of recreational ecstasy: a systematic review of observational evidence. 30 Dec 2008
• Long-term behavioral consequences of prenatal MDMA exposure. 29 Dec 2008
• Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI study. 15 Dec 2008
• The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences. 12 Dec 2008
• Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. 10 Dec 2008
• [Main illegal drugs consumed in France] 29 Nov 2008
• Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain. 28 Oct 2008
• Sustained effects of ecstasy on the human brain: a prospective neuroimaging study in novel users. 5 Oct 2008

See a longer list of these articles.

Technical information about 'N-Methyl-3,4-methylenedioxyamphetamine'

Definition: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.

Chemical name: 1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl-

Registry Number: 42542-10-9

Descriptor UI: D018817

Alternative terms: N-Methyl-3,4-methylenedioxyamphetamine; N Methyl 3,4 methylenedioxyamphetamine; MDMA; Methylenedioxymethamphetamine; Ecstasy (Drug); N-Methyl-3,4-methylenedioxyamphetamine Hydrochloride; Hydrochloride, N-Methyl-3,4-methylenedioxyamphetamine; N Methyl 3,4 methylenedioxyamphetamine Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Hallucinogens; Serotonin Agents; Adrenergic Uptake Inhibitors;

Tree Number: D02.092.471.683.152.670;

Online Note: use N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE (NM) to search N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE 1984-94

History Note: 95; was N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE (NM) 1984-94

Technical Notes: street drug Ecstasy goes here; DF: note short X ref