N-Methylaspartate - Administration & dosage
Research News and Information

Monday, November 23, 2009

Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex.

22 Jun 2009 The current study investigated the contribution of the dorsomedial prefrontal cortex (dmPFC) to instrumental action selection. We found that cell body lesions of the dmPFC, centered on the medial agranular area, spared rats' ability to choose ... Read more...

A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning.

22 Jun 2009 Trace conditioning is considered a model of higher cognitive involvement in simple associative tasks. Studies of trace conditioning have shown that cortical areas and the hippocampal formation are required to associate events that occur at different ... Read more...

Effects of a single postnatal methamphetamine administration on NMDA-induced seizures are sex- and prenatal exposure-specific.

12 May 2009 The aim of our study was to reveal whether acute methamphetamine (MA) administration changes the sensitivity to seizures induced by N-methyl-D-aspartate (NMDA) in prenatally MA-exposed adult rats. Adult rats with respect to sex and female estrous ... Read more...

Latest indexed articles for 'N-Methylaspartate - Administration & dosage'

These are the very latest articles for this heading:

• Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex. 22 Jun 2009
• A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. 22 Jun 2009
• Effects of a single postnatal methamphetamine administration on NMDA-induced seizures are sex- and prenatal exposure-specific. 12 May 2009
• Hippocampal lesions impair rapid learning of a continuous spatial alternation task. 6 May 2009
• Involvement of brain-derived neurotrophic factor in time-dependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate. Apr 2009
• Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals. 30 Mar 2009
• Ethanol aggravates itch-related scratching in hairless mice developing atopic dermatitis. 30 Mar 2009
• Role of glutamate NMDA receptors and nitric oxide located within the periaqueductal gray on defensive behaviors in mice confronted by predator. 23 Feb 2009
• Cardiovascular and thermal responses evoked from the periaqueductal grey require neuronal activity in the hypothalamus. 24 Jan 2009
• Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue. 5 Jan 2009
• Activation of c-Jun N-terminal kinase cascades is involved in part of the neuronal degeneration induced by trimethyltin in cortical neurons of mice. 31 Dec 2008
• An intraperitoneally administered pentapeptide protects against Abeta (1-42) induced neuronal excitation in vivo. 30 Dec 2008
• NMDA preconditioning and neuroprotection in vivo: delayed onset of kainic acid-induced neurodegeneration and c-Fos attenuation in CA3a neurons. 14 Dec 2008
• Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats. 17 Nov 2008
• Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions. 9 Nov 2008
• Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo. 29 Sep 2008
• Anxiogenic-like effects induced by NMDA receptor activation are prevented by inhibition of neuronal nitric oxide synthase in the periaqueductal gray in mice. 2 Sep 2008
• Fos expression following activation of the ventral pallidum in normal rats and in a model of Parkinson's Disease: implications for limbic system and basal ganglia interactions. 27 Jul 2008
• Chronic NMDA administration increases neuroinflammatory markers in rat frontal cortex: cross-talk between excitotoxicity and neuroinflammation. 22 May 2008
• Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice. 17 May 2008

See a longer list of these articles.

Technical information about 'N-Methylaspartate'

Definition: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).

Chemical name: D-Aspartic acid, N-methyl-

Registry Number: 6384-92-5

Descriptor UI: D016202

Alternative terms: N-Methylaspartate; N Methylaspartate; NMDA; N-Methyl-D-aspartic Acid; Acid, N-Methyl-D-aspartic; N Methyl D aspartic Acid; N-Methyl-D-aspartate; N Methyl D aspartate;

Related Mesh Headings: Receptors, N-Methyl-D-Aspartate;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Agonists;

Tree Number: D12.125.067.500.400; D12.125.119.170.400;

History Note: 91

Technical Notes: a glutamate agonist; /biosyn /physiol permitted; DF: note short X ref