N-Methylaspartate - Pharmacology
Research News and Information

Saturday, November 21, 2009

Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking.

12 Oct 2009 The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that organizes and stabilizes receptors, ion channels, structural, and signaling proteins necessary for synaptic function. To study the stabilization of proteins ... Read more...

Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine.

29 Sep 2009 Treatment with topiramate may improve negative symptoms in schizophrenia when added to typical antipsychotic drugs (APDs) but not to clozapine. Both dopaminergic and glutamatergic transmissions in the medial prefrontal cortex (mPFC) are facilitated ... Read more...

Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging.

14 Sep 2009 The wake-promoting basal forebrain (BF) is critically involved in sustaining cortical arousal. In the present study, we investigated how aging affects the capacity of the BF to cope with continuous activation during prolonged waking. Increased ... Read more...

Latest indexed articles for 'N-Methylaspartate - Pharmacology'

These are the very latest articles for this heading:

• Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. 12 Oct 2009
• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging. 14 Sep 2009
• Activity of Hb9 interneurons during fictive locomotion in mouse spinal cord. 14 Sep 2009
• Selective expression of ligand-gated ion channels in L5 pyramidal cell axons. 14 Sep 2009
• Remote spatial memory and the hippocampus: effect of early and extensive training in the radial maze. 25 Aug 2009
• Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. 25 Aug 2009
• Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro. 28 Jul 2009
• Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum. 15 Jul 2009
• GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. 14 Jul 2009
• [Effects of NMDA and metabotropic glutamate receptors antagonists in working memory task in rats] 29 Jun 2009
• Endocannabinoids mediate tachykinin-induced effects in the lamprey locomotor network. 29 Jun 2009
• Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice. 25 Jun 2009
• The medial hypothalamic defensive circuit and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) induced fear: comparison of electrolytic and neurotoxic lesions. 23 Jun 2009
• A new method to study sensory modulation of locomotor networks by activation of thermosensitive cutaneous afferents using a hindlimb attached spinal cord preparation. 16 Jun 2009
• Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics. 9 Jun 2009
• Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. 31 May 2009
• The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. 30 May 2009
• Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C. 26 May 2009
• In mice lacking V2a interneurons, gait depends on speed of locomotion. 25 May 2009

See a longer list of these articles.

Technical information about 'N-Methylaspartate'

Definition: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).

Chemical name: D-Aspartic acid, N-methyl-

Registry Number: 6384-92-5

Descriptor UI: D016202

Alternative terms: N-Methylaspartate; N Methylaspartate; NMDA; N-Methyl-D-aspartic Acid; Acid, N-Methyl-D-aspartic; N Methyl D aspartic Acid; N-Methyl-D-aspartate; N Methyl D aspartate;

Related Mesh Headings: Receptors, N-Methyl-D-Aspartate;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Agonists;

Tree Number: D12.125.067.500.400; D12.125.119.170.400;

History Note: 91

Technical Notes: a glutamate agonist; /biosyn /physiol permitted; DF: note short X ref