N-Methylaspartate - Toxicity
Research News and Information

Sunday, November 22, 2009

Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

29 Sep 2009 Glutamate receptor-mediated excitotoxicity and mitochondrial dysfunction appear to play an important role in motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). In the present study we used an organotypic slice culture of chick ... Read more...

Beta-amyloid monomers are neuroprotective.

24 Aug 2009 The 42-aa-long beta-amyloid protein--Abeta(1-42)--is thought to play a central role in the pathogenesis of Alzheimer's disease (AD) (Walsh and Selkoe, 2007). Data from AD brain (Shankar et al., 2008), transgenic APP (amyloid precursor ... Read more...

Insular cortex and consummatory successive negative contrast in the rat.

30 Jul 2009 Rats that are expecting a high value reward (e.g., 1.0 M sucrose) show an exaggerated underresponding when they are instead given a low value reward (e.g., 0.15% saccharin), an effect termed successive negative contrast (SNC). In the present ... Read more...

Latest indexed articles for 'N-Methylaspartate - Toxicity'

These are the very latest articles for this heading:

• Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
• Beta-amyloid monomers are neuroprotective. 24 Aug 2009
• Insular cortex and consummatory successive negative contrast in the rat. 30 Jul 2009
• Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact. 30 Jun 2009
• GIF-0173 protects against cerebral infarction through DP1 receptor activation. 30 Jun 2009
• Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. 29 Jun 2009
• Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity. 25 Jun 2009
• Making context memories independent of the hippocampus. 22 Jun 2009
• Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex. 22 Jun 2009
• A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. 22 Jun 2009
• Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons. 8 Jun 2009
• Additional evidence for intact appetitive trace conditioning in hippocampal-lesioned rats. 30 May 2009
• Effects of a single postnatal methamphetamine administration on NMDA-induced seizures are sex- and prenatal exposure-specific. 12 May 2009
• Anxiolytic-like effects produced by bilateral lesion of the periaqueductal gray in mice: Influence of concurrent nociceptive stimulation. May 2009
• Adult neural stem/progenitor cells reduce NMDA-induced excitotoxicity via the novel neuroprotective peptide pentinin. 29 Apr 2009
• Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. 27 Apr 2009
• Neuroprotection by the NR3A subunit of the NMDA receptor. 20 Apr 2009
• Post-training excitotoxic lesions of the dorsal hippocampus attenuate generalization in auditory delay fear conditioning. 30 Mar 2009
• Goal-directed responding is sensitive to lesions to the prelimbic cortex or basolateral nucleus of the amygdala but not to their disconnection. 30 Mar 2009
• Interleukin-10 and interleukin-10 receptor-I are upregulated in glial cells after an excitotoxic injury to the postnatal rat brain. 30 Mar 2009

See a longer list of these articles.

Technical information about 'N-Methylaspartate'

Definition: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).

Chemical name: D-Aspartic acid, N-methyl-

Registry Number: 6384-92-5

Descriptor UI: D016202

Alternative terms: N-Methylaspartate; N Methylaspartate; NMDA; N-Methyl-D-aspartic Acid; Acid, N-Methyl-D-aspartic; N Methyl D aspartic Acid; N-Methyl-D-aspartate; N Methyl D aspartate;

Related Mesh Headings: Receptors, N-Methyl-D-Aspartate;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Agonists;

Tree Number: D12.125.067.500.400; D12.125.119.170.400;

History Note: 91

Technical Notes: a glutamate agonist; /biosyn /physiol permitted; DF: note short X ref