N-Methylaspartate
Research News and Information

Saturday, November 21, 2009

Angelman syndrome: current understanding and research prospects.

30 Oct 2009 Angelman syndrome is a neurogenetic disorder characterized by developmental delay, severe intellectual disability, absent speech, exuberant behavior with happy demeanor, motor impairment, and epilepsy, due to deficient UBE3A gene expression that may ... Read more...

Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking.

12 Oct 2009 The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that organizes and stabilizes receptors, ion channels, structural, and signaling proteins necessary for synaptic function. To study the stabilization of proteins ... Read more...

Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

29 Sep 2009 Glutamate receptor-mediated excitotoxicity and mitochondrial dysfunction appear to play an important role in motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). In the present study we used an organotypic slice culture of chick ... Read more...

Latest indexed articles for 'N-Methylaspartate'

These are the very latest articles for this heading:

• Angelman syndrome: current understanding and research prospects. 30 Oct 2009
• Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. 12 Oct 2009
• Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. 21 Sep 2009
• Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging. 14 Sep 2009
• Activity of Hb9 interneurons during fictive locomotion in mouse spinal cord. 14 Sep 2009
• Selective expression of ligand-gated ion channels in L5 pyramidal cell axons. 14 Sep 2009
• Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes. 30 Aug 2009
• Remote spatial memory and the hippocampus: effect of early and extensive training in the radial maze. 25 Aug 2009
• Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. 25 Aug 2009
• Beta-amyloid monomers are neuroprotective. 24 Aug 2009
• Nitric oxide and pain: 'Something old, something new'. 19 Aug 2009
• Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage. 13 Aug 2009
• Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. 5 Aug 2009
• Insular cortex and consummatory successive negative contrast in the rat. 30 Jul 2009
• Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro. 28 Jul 2009
• More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation. 20 Jul 2009
• Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum. 15 Jul 2009
• GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. 14 Jul 2009

See a longer list of these articles.

Technical information about 'N-Methylaspartate'

Definition: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).

Chemical name: D-Aspartic acid, N-methyl-

Registry Number: 6384-92-5

Descriptor UI: D016202

Alternative terms: N-Methylaspartate; N Methylaspartate; NMDA; N-Methyl-D-aspartic Acid; Acid, N-Methyl-D-aspartic; N Methyl D aspartic Acid; N-Methyl-D-aspartate; N Methyl D aspartate;

Related Mesh Headings: Receptors, N-Methyl-D-Aspartate;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Agonists;

Tree Number: D12.125.067.500.400; D12.125.119.170.400;

History Note: 91

Technical Notes: a glutamate agonist; /biosyn /physiol permitted; DF: note short X ref