NAD - Chemistry
Research News and Information

Monday, November 23, 2009

Disulfide bond formation in yeast NAD+-specific isocitrate dehydrogenase.

20 Sep 2009 The tricarboxylic acid cycle NAD+-specific isocitrate dehydrogenase (IDH) of Saccharomyces cerevisiae is an octameric enzyme composed of four heterodimers of regulatory IDH1 and catalytic IDH2 subunits. Recent structural analyses revealed the close ... Read more...

Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.

13 Sep 2009 Quinone reductases are flavin-containing enzymes that have been implicated in protecting organisms from redox stress and, more recently, as redox switches controlling the action of the proteasome. The reactions of the catalytic cycle of the dimeric ... Read more...

Lignosulfonate-modified electrodes: electrochemical properties and electrocatalysis of NADH oxidation.

30 Aug 2009 Lignosulfonic acid (LS1) and partially desulfonated lignosulfonic acid (LS2) were oxidatively deposited on a preactivated glassy carbon (GC) electrode, giving rise to redox active films showing three distinct redox couples at midpeak potentials (E ... Read more...

Latest indexed articles for 'NAD - Chemistry'

These are the very latest articles for this heading:

• Disulfide bond formation in yeast NAD+-specific isocitrate dehydrogenase. 20 Sep 2009
• Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae. 13 Sep 2009
• Lignosulfonate-modified electrodes: electrochemical properties and electrocatalysis of NADH oxidation. 30 Aug 2009
• Photoinduced DNA cleavage by alpha-, beta-, and gamma-cyclodextrin-bicapped C60 supramolecular complexes. 30 Jul 2009
• Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase. 29 Jul 2009
• Electrochemical sensing and biosensing platform based on chemically reduced graphene oxide. 13 Jul 2009
• Synthesis, radiosynthesis and biological evaluation of 1,4-dihydroquinoline derivatives as new carriers for specific brain delivery. 8 Jul 2009
• Application of artificial neural networks in the prediction of product distribution in electrophoretically mediated microanalysis. 29 Jun 2009
• Characterization of a soluble oxidoreductase from the thermophilic bacterium Carboxydothermus ferrireducens. 16 Jun 2009
• A link between hinge-bending domain motions and the temperature dependence of catalysis in 3-isopropylmalate dehydrogenase. 15 Jun 2009
• Crystal structures of human SIRT3 displaying substrate-induced conformational changes. 14 Jun 2009
• The catalytic mechanism of NADH-dependent reduction of 9,10-phenanthrenequinone by Candida tenuis xylose reductase reveals plasticity in an aldo-keto reductase active site. 10 Jun 2009
• Fabrication of a microfluidic enzyme reactor utilizing magnetic beads. 30 May 2009
• Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure. 23 May 2009
• Molecular properties, functions, and potential applications of NAD kinases. 29 Apr 2009
• The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals. 29 Apr 2009
• Network analysis of biochemical logic for noise reduction and stability: a system of three coupled enzymatic and gates. 14 Apr 2009
• Supramolecular cocaine-aptamer complexes activate biocatalytic cascades. 13 Apr 2009
• Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. 5 Apr 2009
• Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation. 30 Mar 2009

See a longer list of these articles.

Technical information about 'NAD'

Definition: A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Chemical name: Adenosine 5'-(trihydrogen diphosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt

Registry Number: 53-84-9

Descriptor UI: D009243

Alternative terms: NAD; Dihydronicotinamide Adenine Dinucleotide; Adenine Dinucleotide, Dihydronicotinamide; Dinucleotide, Dihydronicotinamide Adenine; Diphosphopyridine Nucleotide; Nucleotide, Diphosphopyridine; Nadide; Nicotinamide-Adenine Dinucleotide; Dinucleotide, Nicotinamide-Adenine; Nicotinamide Adenine Dinucleotide; Coenzyme I; DPN; NADH;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; analogs & derivatives;

Tree Number: D03.438.759.646.138.694; D08.211.589; D13.695.667.138.694; D13.695.827.068.694;

Technical Notes: a coenzyme; NAD or NADP probably correct for indexing of pyridine nucleotides