NAD(P)H Dehydrogenase (Quinone) - Genetics
Research News and Information

Monday, March 22, 2010

Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma.

29 Sep 2009 NAD(P)H: quinone oxidoreductase 1 (NQO1), a cytosolic enzyme which catalyzes the two-electron reduction of quinone compounds, has been suggested to prevent the generation of semiquinone free radicals and reactive oxygen species, thus protecting ... Read more...

Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.

16 Aug 2009 Identifying agents that block tumor initiation is a goal of cancer prevention. The ability of a chemically varied group of agents to induce various drug metabolizing genes in livers of rats was examined. Sprague-Dawley rats were treated for 7 days ... Read more...

Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells.

9 Aug 2009 The transcription factor NF-E2-related nuclear factor 2 (Nrf2) regulates expression of genes that protect cells from oxidative damage. Here, we characterized nitric oxide (*NO)-induced Nrf2-Kelch-like ECH-associated protein 1 (Keap1) signaling and ... Read more...

Latest indexed articles for 'NAD(P)H Dehydrogenase (Quinone) - Genetics'

These are the very latest articles for this heading:

• Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma. 29 Sep 2009
• Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. 16 Aug 2009
• Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. 9 Aug 2009
• Specific IKKbeta inhibitor IV blocks Streptonigrin-induced NF-kappaB activity and potentiates its cytotoxic effect on cancer cells. 30 Jul 2009
• NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. 19 Jul 2009
• Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. 11 Jul 2009
• NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma. 6 Jul 2009
• The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat. 29 Jun 2009
• [Polymorphism of the genes for antioxidant defense enzymes and their association with the development of chronic obstructive pulmonary disease in the population of Bashkortostan] 29 Jun 2009
• NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors. 29 Jun 2009
• Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells. 17 May 2009
• Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues. 29 Apr 2009
• Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. 29 Apr 2009
• Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells. 29 Apr 2009
• High risk of 'de novo' acute myeloid leukaemia in individuals with cytochrome P450 A1 (CYP1A1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) gene defects. 25 Apr 2009
• Restenosis revisited. 8 Apr 2009
• Re: "NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis". 28 Mar 2009
• Effect of dietary genistein on Phase II and antioxidant enzymes in rat liver. 27 Feb 2009
• Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes in a Brazilian population. 27 Feb 2009
• Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells. 22 Feb 2009

See a longer list of these articles.

Technical information about 'NAD(P)H Dehydrogenase (Quinone)'

Definition: A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.

Chemical name: NAD(P)H:(quinone-acceptor) oxidoreductase

Registry Number: EC 1.6.5.2

Descriptor UI: D016660

Alternative terms: NAD(P)H Dehydrogenase (Quinone); Quinone Reductase; Reductase, Quinone; Phylloquinone Reductase; Reductase, Phylloquinone; DT Diaphorase; Diaphorase, DT; Menadione Reductase; Reductase, Menadione; Vitamin K Reductase; Reductase, Vitamin K;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.608.800.500;

Online Note: use NAD(P)H DEHYDROGENASE (QUINONE) (NM) to search NAD(P)H DEHYDROGENASE (QUINONE) 1980-91

History Note: 92; was NAD(P)H DEHYDROGENASE (QUINONE) (NM) 1973-91