NAD
Research News and Information

Sunday, November 22, 2009

Modular coenzyme specificity: a domain-swopped chimera of glutamate dehydrogenase.

30 Oct 2009 Domain-swopped chimeras of the glutamate dehydrogenases from Clostridium symbiosum (CsGDH) (NAD(+)-specific) and Escherichia coli (EcGDH) (NADP(+)-specific) have been produced, with the aim of testing the localization of determinants of coenzyme ... Read more...

Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans.

30 Oct 2009 Nicotinamide adenine dinucleotide (NAD(+)) is a central molecule in cellular metabolism and an obligate co-substrate for NAD(+)-consuming enzymes, which regulate key biological processes such as longevity and stress responses. Although NAD(+) ... Read more...

The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.

21 Oct 2009 There is emerging recognition of a novel fuel and redox sensing regulatory program that controls cellular adaptation via nonhistone protein lysine residue acetyl posttranslation modifications. This program functions in tissues with high energy ... Read more...

Latest indexed articles for 'NAD'

These are the very latest articles for this heading:

• Modular coenzyme specificity: a domain-swopped chimera of glutamate dehydrogenase. 30 Oct 2009
• Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans. 30 Oct 2009
• The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology. 21 Oct 2009
• Metabolomics for biotransformations: Intracellular redox cofactor analysis and enzyme kinetics offer insight into whole cell processes. 29 Sep 2009
• Reconstitution of heterochromatin-dependent transcriptional gene silencing. 22 Sep 2009
• Disulfide bond formation in yeast NAD+-specific isocitrate dehydrogenase. 20 Sep 2009
• Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae. 13 Sep 2009
• Lignosulfonate-modified electrodes: electrochemical properties and electrocatalysis of NADH oxidation. 30 Aug 2009
• The role of sirtuins in the control of metabolic homeostasis. 30 Aug 2009
• SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced. 27 Aug 2009
• Storage and secretion of beta-NAD, ATP and dopamine in NGF-differentiated rat pheochromocytoma PC12 cells. 25 Aug 2009
• The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. 22 Aug 2009
• Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli. 16 Aug 2009
• Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. 12 Aug 2009
• Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. 4 Aug 2009
• The potential of dual camera systems for multimodal imaging of cardiac electrophysiology and metabolism. 3 Aug 2009
• Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD(+)-dependent SIRT1 activity. 3 Aug 2009
• Suppression of mitochondrial function by oxidatively truncated phospholipids is reversible, aided by bid, and suppressed by Bcl-XL. 2 Aug 2009
• Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system. Aug 2009
• [Exogenous succinate reduces vibration-induced disorders of energy metabolism in rabbit cardiomyocytes] 30 Jul 2009

See a longer list of these articles.

Technical information about 'NAD'

Definition: A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Chemical name: Adenosine 5'-(trihydrogen diphosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt

Registry Number: 53-84-9

Descriptor UI: D009243

Alternative terms: NAD; Dihydronicotinamide Adenine Dinucleotide; Adenine Dinucleotide, Dihydronicotinamide; Dinucleotide, Dihydronicotinamide Adenine; Diphosphopyridine Nucleotide; Nucleotide, Diphosphopyridine; Nadide; Nicotinamide-Adenine Dinucleotide; Dinucleotide, Nicotinamide-Adenine; Nicotinamide Adenine Dinucleotide; Coenzyme I; DPN; NADH;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; analogs & derivatives;

Tree Number: D03.438.759.646.138.694; D08.211.589; D13.695.667.138.694; D13.695.827.068.694;

Technical Notes: a coenzyme; NAD or NADP probably correct for indexing of pyridine nucleotides