Naloxone - Pharmacology
Research News and Information

Tuesday, November 24, 2009

Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception.

29 Sep 2009 The authors have recently demonstrated that the high serum estradiol level during the proestrus phase of the estrous cycle and that the administration of estradiol or progesterone in ovariectomized female and of testosterone in orchiectomized male ... Read more...

Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

29 Sep 2009 Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats ... Read more...

Fentanyl inhibits glucose-stimulated insulin release from beta-cells in rat pancreatic islets.

5 Sep 2009 AIM: To explore the effects of fentanyl on insulin release from freshly isolated rat pancreatic islets in static culture. METHODS: Islets were isolated from the pancreas of mature Sprague Dawley rats by common bile duct intraductal collagenase V ... Read more...

Latest indexed articles for 'Naloxone - Pharmacology'

These are the very latest articles for this heading:

• Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception. 29 Sep 2009
• Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. 29 Sep 2009
• Fentanyl inhibits glucose-stimulated insulin release from beta-cells in rat pancreatic islets. 5 Sep 2009
• Increasing the duration of isoflurane anesthesia decreases the minimum alveolar anesthetic concentration in 7-day-old but not in 60-day-old rats. 30 Aug 2009
• Activation of the opioidergic descending pain control system underlies placebo analgesia. 25 Aug 2009
• Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection. Aug 2009
• Running and addiction: precipitated withdrawal in a rat model of activity-based anorexia. 30 Jul 2009
• Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats. 30 Jul 2009
• Naloxone decreases the inhibitory effect of ethanol on the release of arginine-vasopressin induced by physical exercise in man. 30 Jul 2009
• Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice. 30 Jul 2009
• The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors. 30 Jul 2009
• Rat dorsal horn nociceptive-specific neurons are more sensitive than wide dynamic range neurons to depression by immobilizing doses of volatile anesthetics: an effect partially reversed by the opioid receptor antagonist naloxone. 30 Jul 2009
• The endocannabinoid transport inhibitor AM404 modulates nociception in cholestasis. 14 Jul 2009
• The Rac GTPase-activating bacterial protein toxin CNF1 induces analgesia up-regulating mu-opioid receptors. 13 Jul 2009
• Distinct opioid circuits determine the palatability and the desirability of rewarding events. 11 Jul 2009
• Evidence for opioid-induced release of glutamate in guinea pig longitudinal muscle-myenteric plexus strip. 30 Jun 2009
• Methylnaltrexone reduced body weight gain in ob/ob mice. 29 Jun 2009
• Protein kinase C mediates the effects of delta-opioid receptor stimulation on survival and apoptosis in neonatal cardiomyocytes cultured in serum-deprived condition. 29 Jun 2009
• Interaction of morphine but not fentanyl with cerebral alpha2-adrenoceptors in alpha2-adrenoceptor knockout mice. 29 Jun 2009
• Phosphodiesterase inhibition by naloxone augments the inotropic actions of beta-adrenergic stimulation. 28 Jun 2009

See a longer list of these articles.

Technical information about 'Naloxone'

Definition: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

Chemical name: Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-

Registry Number: 465-65-6

Descriptor UI: D009270

Alternative terms: Naloxone; Naloxone Hydrochloride; Hydrochloride, Naloxone; Naloxone Hydrochloride Dihydride; Dihydride, Naloxone Hydrochloride; Hydrochloride Dihydride, Naloxone; Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; Naloxone Abello; Abello, Naloxone; Abello Brand of Naloxone Hydrochloride; Narcan; Endo Brand of Naloxone Hydrochloride; Lamepro Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Bristol Myers Squibb Brand of Naloxone Hydrochloride; Narcanti; Boots Brand of Naloxone Hydrochloride; United Drug Brand of Naloxone Hydrochloride; Nalone; SERB Brand of Naloxone Hydrochloride; Naloxon Curamed; Curamed, Naloxon; Curamed Brand of Naloxone Hydrochloride; Naloxon-ratiopharm; Naloxon ratiopharm; Naloxonratiopharm; ratiopharm Brand of Naloxone Hydrochloride; Naloxone Hydrobromide; Hydrobromide, Naloxone; Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Narcotic Antagonists;

Tree Number: D03.132.577.249.706; D03.549.686.750; D03.605.497.750; D04.615.723.795.706;

History Note: 73(72)