Naloxone
Research News and Information

Sunday, November 22, 2009

An ultra-low dose of naloxone added to lidocaine or lidocaine-fentanyl mixture prolongs axillary brachial plexus blockade.

30 Oct 2009 INTRODUCTION: In this prospective, randomized, double-blind study, we evaluated the effect of an ultra-low dose of naloxone added to lidocaine and fentanyl mixture on the onset and duration of axillary brachial plexus block. METHODS: One hundred ... Read more...

Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception.

29 Sep 2009 The authors have recently demonstrated that the high serum estradiol level during the proestrus phase of the estrous cycle and that the administration of estradiol or progesterone in ovariectomized female and of testosterone in orchiectomized male ... Read more...

Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

29 Sep 2009 Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats ... Read more...

Latest indexed articles for 'Naloxone'

These are the very latest articles for this heading:

• An ultra-low dose of naloxone added to lidocaine or lidocaine-fentanyl mixture prolongs axillary brachial plexus blockade. 30 Oct 2009
• Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception. 29 Sep 2009
• Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. 29 Sep 2009
• The clinical efficacy and abuse potential of combination buprenorphine-naloxone in the treatment of opioid dependence. 29 Sep 2009
• The synergistic interaction between morphine and maprotiline after intrathecal injection in rats. 29 Sep 2009
• Fentanyl inhibits glucose-stimulated insulin release from beta-cells in rat pancreatic islets. 5 Sep 2009
• Effectiveness of two opioid antagonists in treating opioid-induced constipation. 30 Aug 2009
• Increasing the duration of isoflurane anesthesia decreases the minimum alveolar anesthetic concentration in 7-day-old but not in 60-day-old rats. 30 Aug 2009
• Activation of the opioidergic descending pain control system underlies placebo analgesia. 25 Aug 2009
• Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection. Aug 2009
• Injection of medications used in opioid substitution treatment in Australia after the introduction of a mixed partial agonist-antagonist formulation. Aug 2009
• Running and addiction: precipitated withdrawal in a rat model of activity-based anorexia. 30 Jul 2009
• Development of a behavior model of pain induced by experimental tooth movement in rats. 30 Jul 2009
• Intranasal flumazenil and naloxone to reverse over-sedation in a child undergoing dental restorations. 30 Jul 2009
• Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats. 30 Jul 2009
• Naloxone decreases the inhibitory effect of ethanol on the release of arginine-vasopressin induced by physical exercise in man. 30 Jul 2009
• Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice. 30 Jul 2009
• The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors. 30 Jul 2009
• Rat dorsal horn nociceptive-specific neurons are more sensitive than wide dynamic range neurons to depression by immobilizing doses of volatile anesthetics: an effect partially reversed by the opioid receptor antagonist naloxone. 30 Jul 2009
• Relaxing prescribing of naloxone could save lives of drug users, expert says. 19 Jul 2009

See a longer list of these articles.

Technical information about 'Naloxone'

Definition: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

Chemical name: Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-

Registry Number: 465-65-6

Descriptor UI: D009270

Alternative terms: Naloxone; Naloxone Hydrochloride; Hydrochloride, Naloxone; Naloxone Hydrochloride Dihydride; Dihydride, Naloxone Hydrochloride; Hydrochloride Dihydride, Naloxone; Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; Naloxone Abello; Abello, Naloxone; Abello Brand of Naloxone Hydrochloride; Narcan; Endo Brand of Naloxone Hydrochloride; Lamepro Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Bristol Myers Squibb Brand of Naloxone Hydrochloride; Narcanti; Boots Brand of Naloxone Hydrochloride; United Drug Brand of Naloxone Hydrochloride; Nalone; SERB Brand of Naloxone Hydrochloride; Naloxon Curamed; Curamed, Naloxon; Curamed Brand of Naloxone Hydrochloride; Naloxon-ratiopharm; Naloxon ratiopharm; Naloxonratiopharm; ratiopharm Brand of Naloxone Hydrochloride; Naloxone Hydrobromide; Hydrobromide, Naloxone; Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Narcotic Antagonists;

Tree Number: D03.132.577.249.706; D03.549.686.750; D03.605.497.750; D04.615.723.795.706;

History Note: 73(72)