Naphthoquinones - Pharmacology
Research News and Information

Monday, November 23, 2009

Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation.

6 Sep 2009 In order to elucidate the effect on mammal systems of new derivatives from 2-hydroxy-3-allyl-naphthoquinone, alpha-iodinated naphthofuranquinone (NPPN-3223), beta-iodinated naphthofuranquinone (NPPN-3222) and beta-methyl naphthofuranquinone ... Read more...

The PqrR transcriptional repressor of Pseudomonas aeruginosa transduces redox signals via an iron-containing prosthetic group.

26 Aug 2009 Inducible defenses against oxidative stress are coordinated by redox-sensitive transcription factors that transduce oxidative damage into differential gene expression. The opportunistic human pathogen Pseudomonas aeruginosa has evolved under ... Read more...

Cribrarione C, a naphthoquinone pigment from the myxomycete Cribraria meylanii.

30 Jul 2009 Chemical investigation of field-collected fruit bodies of the myxomycete Cribraria meylanii resulted in the isolation of a naphthoquinone pigment, cribrarione C, and its structure was elucidated by spectral data as ... Read more...

Latest indexed articles for 'Naphthoquinones - Pharmacology'

These are the very latest articles for this heading:

• Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation. 6 Sep 2009
• The PqrR transcriptional repressor of Pseudomonas aeruginosa transduces redox signals via an iron-containing prosthetic group. 26 Aug 2009
• Cribrarione C, a naphthoquinone pigment from the myxomycete Cribraria meylanii. 30 Jul 2009
• Superoxide protects Escherichia coli from bleomycin mediated lethality. 15 Jul 2009
• Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation. 11 Jul 2009
• Lung mast cells are a source of secreted phospholipases A2. 7 Jul 2009
• Induction of apoptosis by rhinacanthone isolated from Rhinacanthus nasutus roots in human cervical carcinoma cells. 29 Jun 2009
• Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin. 29 Jun 2009
• In vitro antifilarial activity of glutathione S-transferase inhibitors. 26 Jun 2009
• Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells. 21 Jun 2009
• Pin1 affects Tau phosphorylation in response to Abeta oligomers. 7 Jun 2009
• Diospyrone, crassiflorone and plumbagin: three antimycobacterial and antigonorrhoeal naphthoquinones from two Diospyros spp. 5 Jun 2009
• Functional and expression analyses of the cop operon, required for copper resistance in Agrobacterium tumefaciens. 3 Jun 2009
• Part 2: influence of 2-euryfuryl-1,4-naphthoquinone and its peri-hydroxy derivatives on both cell death and metabolism of TLT cells, a murine hepatoma cell line. modulation of cytotoxicity by vitamin C. 30 May 2009
• Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family. 17 May 2009
• Spatial distribution, kinetics, signaling and cytokine production during homeostasis driven proliferation of CD4+ T cells. 15 May 2009
• Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent. 14 May 2009
• Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. 13 May 2009
• Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells. 3 May 2009
• Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Naphthoquinones'

Definition: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.

Registry Number: 0

Descriptor UI: D009285

Alternative terms: Naphthoquinones; Naphthalenediones; Naphthazarins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.426.559.847.638.721; D02.806.550; D04.615.638.721;