National Cancer Institute (U.S.)
Research News and Information

Sunday, November 22, 2009

A perspective on challenges and issues in biomarker development and drug and biomarker codevelopment.

21 Oct 2009 A workshop sponsored by the National Cancer Institute and the US Food and Drug Administration addressed past lessons learned and ongoing challenges faced in biomarker development and drug and biomarker codevelopment. Participants agreed that ... Read more...

Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity.

14 Sep 2009 BACKGROUND: Small molecules that bind reversibly to DNA are among the antitumor drugs currently used in chemotherapy. In the pursuit of a more rational approach to cancer chemotherapy based upon these molecules, it is necessary to exploit the ... Read more...

Partial nephrectomy after previous radio frequency ablation: the National Cancer Institute experience.

14 Sep 2009 PURPOSE: Development of new renal tumors or recurrence after radio frequency ablation not amendable for repeat ablation presents a difficult therapeutic dilemma. We report on the outcomes of partial nephrectomy on kidneys previously treated with ... Read more...

Latest indexed articles for 'National Cancer Institute (U.S.)'

These are the very latest articles for this heading:

• A perspective on challenges and issues in biomarker development and drug and biomarker codevelopment. 21 Oct 2009
• Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity. 14 Sep 2009
• Partial nephrectomy after previous radio frequency ablation: the National Cancer Institute experience. 14 Sep 2009
• Interview with director John E. Niederhuber, M.D.: National Cancer Institute stakes out new directions with stimulus funds. 31 Aug 2009
• United States military contributions to the National Cancer Institute. 30 Aug 2009
• We have met the enemy and he is us! 30 Aug 2009
• What works to prevent adolescent smoking? A systematic review of the National Cancer Institute's Research-Tested Intervention Programs. 30 Aug 2009
• 2009 Biospecimen research network symposium: advancing cancer research through biospecimen science. 23 Aug 2009
• [Organization of the pediatric radiation oncology in France] 16 Aug 2009
• StatBite: Stimulus funding: where does the NCI propose to invest? 11 Aug 2009
• Bottom-line reality tempers cancer researchers' excitement. 11 Aug 2009
• Stimulus funds force hard look at comparative effectiveness research. 26 Jul 2009
• Comparison of commission on cancer-approved and -nonapproved hospitals in the United States: implications for studies that use the National Cancer Data Base. 25 Jul 2009
• Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity. 5 Jul 2009
• Oncology's first Phase 0 trial. 5 Jul 2009
• Scoring ligand similarity in structure-based virtual screening. 29 Jun 2009
• Evidence-based analysis of the conclusion: what to do without a treatment algorithm. 29 Jun 2009
• Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors. 21 Jun 2009
• Lymphocytes, B lymphocytes, and clonal CLL cells: observations on the impact of the new diagnostic criteria in the 2008 Guidelines for Chronic Lymphocytic Leukemia (CLL). 16 Jun 2009
• The proposed diagnostic criteria change for chronic lymphocytic leukemia: unintended consequences? 16 Jun 2009

See a longer list of these articles.

Technical information about 'National Cancer Institute (U.S.)'

Definition: Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.

Descriptor UI: D054547

Alternative terms: National Cancer Institute (U.S.); National Cancer Institute; NCI (US);

Allowable Qualifiers: classification; economics; history; legislation & jurisprudence; organization & administration; standards; trends; utilization; statistics & numerical data; ethics;

Tree Number: I01.409.137.500.600.480.150; N03.540.348.500.500.600.480.150;

History Note: 2008

Technical Notes: add UNITED STATES (NIM); research support by this agency is checked as RESEARCH SUPPORT, N.I.H., EXTRAMURAL or RESEARCH SUPPORT, N.I.H., INTRAMURAL; CATALOG: use NAF entry