Nephrosclerosis - Drug therapy
Research News and Information

Sunday, November 22, 2009

G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.

30 Dec 2008 BACKGROUND: African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled ... Read more...

Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.

30 Aug 2008 BACKGROUND: In this study, we tested the hypothesis that long-term Rho-kinase inhibition would reverse nitro-L-arginine methyl ester-exacerbated nephrosclerosis in spontaneously hypertensive rats and attempted to elucidate the mechanism involved. ... Read more...

Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.

24 May 2008 There is increasing evidence for a role of somatic cellular senescence in physiological aging but also in injury and disease. Cell cycle inhibitor p16(INK4a) is the key mediator for stress and aberrant signaling induced senescence. Here we report ... Read more...

Latest indexed articles for 'Nephrosclerosis - Drug therapy'

These are the very latest articles for this heading:

• G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. 30 Dec 2008
• Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. 30 Aug 2008
• Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. 24 May 2008
• Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. 29 Apr 2007
• Chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-beta1 mRNA ameliorates renal injury in hypertensive rats. 27 Feb 2007
• Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. 30 Oct 2006
• [Expression of p27 in rat kidney with unilateral ureteral obstruction and the therapeutic effect of enalapril] 29 Sep 2006
• [P21 expression in renal interstitial fibrosis and regulative effect of enalapril] 29 Sep 2006
• Dr. Yang Nizhi's experience in treating benign arteriolar nephrosclerosis. 27 Feb 2006
• Transient improvement of hypertension-induced chronic renal failure with mycophenolate mofetil treatment. 30 Dec 2005
• Inhibitory effect of pravastatin on transforming growth factor beta1-inducible gene h3 expression in a rat model of chronic cyclosporine nephropathy. 20 Nov 2005
• Effects of valsartan on the progression of chronic renal insufficiency in patients with nondiabetic renal diseases. 30 Oct 2005
• Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression. 25 Apr 2005
• Life-threatening hyperkalemia during a combined therapy with the angiotensin receptor blocker candesartan and spironolactone. 30 Dec 2004
• [Profibrotic effects of aldosterone] 29 Jul 2004
• [Preventive and therapeutic effects of astragalus and angelica mixture on renal tubulointerstitial fibrosis after unilateral ureteral obstruction in rats] 30 Mar 2004
• Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR model. 15 Mar 2004
• [Diagnosis of and therapy for renal hypertension] 8 Mar 2004
• Hypertensive nephrosclerosis: update. 28 Feb 2004
• [Hypertensive nephrosclerosis] 28 Feb 2004

See a longer list of these articles.

Technical information about 'Nephrosclerosis'

Definition: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.

Descriptor UI: D009400

Alternative terms: Nephrosclerosis; Nephroscleroses;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C12.777.419.610; C13.351.968.419.610;