Neural Cell Adhesion Molecules - Administration & dosage
Research News and Information

Monday, November 23, 2009

Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats.

12 Dec 2008 The FGL peptide is a neural cell adhesion molecule-derived fibroblast growth factor receptor agonist. FGL has both neurotrophic and memory enhancing properties. Neonatal phencyclidine (PCP) treatment on postnatal days 7, 9, and 11 has been shown to ... Read more...

A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35.

14 Jan 2007 By means of i.c.v. administration of preaggregated oligomeric beta-amyloid (Abeta)25-35 peptide it was possible in rats to generate neuropathological signs related to those of early stages of Alzheimer's disease (AD). Abeta25-35-administration ... Read more...

Tolerability, safety and pharmacokinetics of the FGLL peptide, a novel mimetic of neural cell adhesion molecule, following intranasal administration in healthy volunteers.

30 Dec 2006 BACKGROUND: The FG loop peptide (FGL(L)), a novel mimetic of the neural cell adhesion molecule (NCAM), is in clinical development for neurodegenerative disorders such as Alzheimer's disease. Preclinical studies in rats, dogs and monkeys have ... Read more...

Latest indexed articles for 'Neural Cell Adhesion Molecules - Administration & dosage'

These are the very latest articles for this heading:

• Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats. 12 Dec 2008
• A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35. 14 Jan 2007
• Tolerability, safety and pharmacokinetics of the FGLL peptide, a novel mimetic of neural cell adhesion molecule, following intranasal administration in healthy volunteers. 30 Dec 2006
• A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo. 29 Sep 2005
• The dynamics of precursor cells in the olfactory epithelium of juvenile and adult guinea pigs. 18 Jan 2004
• Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy. 30 Oct 2001

See a longer list of these articles.

Technical information about 'Neural Cell Adhesion Molecules'

Definition: Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)

Registry Number: 0

Descriptor UI: D019006

Alternative terms: Neural Cell Adhesion Molecules; NCAM; Neural Cell Adhesion Molecule; Cell Adhesion Molecules, Neural; Cell Adhesion Molecule, Neural;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.395.550.200.250.520; D12.776.543.550.200.250.520; D23.050.301.350.250.520;

History Note: 96

Technical Notes: NCAM: note X ref NEURAL CELL ADHESION MOLECULE but do not confuse this X ref with NEURONAL CELL ADHESION MOLECULES see CELL ADHESION MOLECULES, NEURONAL