Neural Cell Adhesion Molecules - Agonists
Research News and Information

Sunday, November 22, 2009

Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.

13 Feb 2009 Septal cholinergic neurons project to the hippocampus and release acetylcholine, a neurotransmitter involved in learning and memory. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing acetylcholine. Promoting ChAT activity ... Read more...

Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats.

12 Dec 2008 The FGL peptide is a neural cell adhesion molecule-derived fibroblast growth factor receptor agonist. FGL has both neurotrophic and memory enhancing properties. Neonatal phencyclidine (PCP) treatment on postnatal days 7, 9, and 11 has been shown to ... Read more...

Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL.

29 Sep 2008 The neural cell adhesion molecule (NCAM) plays a pivotal role in brain plasticity. Brain plasticity itself has a crucial role in the development of depression. The aim of this study was to analyze whether NCAM-deficient (NCAM(-/-)) mice exhibit ... Read more...

Latest indexed articles for 'Neural Cell Adhesion Molecules - Agonists'

These are the very latest articles for this heading:

• Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand. 13 Feb 2009
• Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats. 12 Dec 2008
• Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL. 29 Sep 2008
• A role for NCAM in depression and antidepressant actions? (Commentary on Aonurm-Helm et al.). 29 Sep 2008
• A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation. 26 Apr 2004
• NCAM mimetic peptides: Pharmacological and therapeutic potential. 30 Dec 2003
• Post-training administration of a synthetic peptide ligand of the neural cell adhesion molecule, C3d, attenuates long-term expression of contextual fear conditioning. 30 Dec 2002
• A peptide agonist of the neural cell adhesion molecule (NCAM), C3, protects against developmental defects induced by a teratogen pyrimethamine. 30 Oct 2002

See a longer list of these articles.

Technical information about 'Neural Cell Adhesion Molecules'

Definition: Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)

Registry Number: 0

Descriptor UI: D019006

Alternative terms: Neural Cell Adhesion Molecules; NCAM; Neural Cell Adhesion Molecule; Cell Adhesion Molecules, Neural; Cell Adhesion Molecule, Neural;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.395.550.200.250.520; D12.776.543.550.200.250.520; D23.050.301.350.250.520;

History Note: 96

Technical Notes: NCAM: note X ref NEURAL CELL ADHESION MOLECULE but do not confuse this X ref with NEURONAL CELL ADHESION MOLECULES see CELL ADHESION MOLECULES, NEURONAL