Neural Cell Adhesion Molecules - Pharmacology
Research News and Information

Monday, November 23, 2009

A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation.

30 May 2009 Microglial cell activity increases in the rat hippocampus during normal brain aging. The neural cell adhesion molecule (NCAM)-derived mimetic peptide, FG loop (FGL), acts as an anti-inflammatory agent in the hippocampus of the aged rat, promoting ... Read more...

Transcriptional regulation of PSA-NCAM expression by NMDA receptor activation in RA-differentiated C6 glioma cultures.

Mar 2009 N-Methyl-d-aspartate (NMDA) receptors exhibit a dichotomy of signaling with both toxic and plastic responses. Recent reports have shown that exposure to subtoxic concentration of NMDA results in a neuroprotective state that was measured when these ... Read more...

Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats.

12 Dec 2008 The FGL peptide is a neural cell adhesion molecule-derived fibroblast growth factor receptor agonist. FGL has both neurotrophic and memory enhancing properties. Neonatal phencyclidine (PCP) treatment on postnatal days 7, 9, and 11 has been shown to ... Read more...

Latest indexed articles for 'Neural Cell Adhesion Molecules - Pharmacology'

These are the very latest articles for this heading:

• A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation. 30 May 2009
• Transcriptional regulation of PSA-NCAM expression by NMDA receptor activation in RA-differentiated C6 glioma cultures. Mar 2009
• Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats. 12 Dec 2008
• Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL. 29 Sep 2008
• The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. 30 Mar 2008
• Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule. 30 Jan 2008
• A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study. 30 Dec 2007
• Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells. 29 Dec 2006
• A neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention. 17 Jun 2006
• Neural cell adhesion molecule induces intracellular signaling via multiple mechanisms of Ca2+ homeostasis. 27 Feb 2006
• Combination of engineered neural cell adhesion molecules and GDF-5 for improved neurite extension in nerve guide concepts. 21 Feb 2006
• Peripheral nerve regeneration in cell adhesive peptide incorporated collagen tubes in rat sciatic nerve -- early and better functional regain. 29 Nov 2005
• The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. 29 Apr 2005
• An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. 30 Oct 2004
• ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation. 30 Oct 2004
• Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells. 13 Jun 2004
• A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation. 26 Apr 2004
• Directed nerve outgrowth is enhanced by engineered glial substrates. 30 Oct 2003
• The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neuronal differentiation and survival. 30 Jan 2003
• Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type. 29 Dec 2002

See a longer list of these articles.

Technical information about 'Neural Cell Adhesion Molecules'

Definition: Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)

Registry Number: 0

Descriptor UI: D019006

Alternative terms: Neural Cell Adhesion Molecules; NCAM; Neural Cell Adhesion Molecule; Cell Adhesion Molecules, Neural; Cell Adhesion Molecule, Neural;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.395.550.200.250.520; D12.776.543.550.200.250.520; D23.050.301.350.250.520;

History Note: 96

Technical Notes: NCAM: note X ref NEURAL CELL ADHESION MOLECULE but do not confuse this X ref with NEURONAL CELL ADHESION MOLECULES see CELL ADHESION MOLECULES, NEURONAL