Neuregulin-1 - Genetics
Research News and Information

Sunday, November 22, 2009

HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells.

29 Nov 2009 HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key ... Read more...

Propagation of spreading depression inversely correlates with cortical myelin content.

30 Aug 2009 OBJECTIVE: Cortical myelin can be severely affected in patients with demyelinating disorders of the central nervous system. However, the functional implication of cortical demyelination remains elusive. In this study, we investigated whether ... Read more...

Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population.

30 Jul 2009 CONTEXT: Neuregulin 1 (NRG1), a growth factor involved in neurodevelopment, myelination, neurotransmitter receptor expression, and synaptic plasticity, first joined the list of candidate genes for schizophrenia when a 7-marker haplotype at the 5' ... Read more...

Latest indexed articles for 'Neuregulin-1 - Genetics'

These are the very latest articles for this heading:

• HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells. 29 Nov 2009
• Propagation of spreading depression inversely correlates with cortical myelin content. 30 Aug 2009
• Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population. 30 Jul 2009
• Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study. 26 Jun 2009
• Upregulation of NRG-1 and VAMP-1 in human brain aggregates exposed to clozapine. 5 Jun 2009
• Study of inhibition effect of herceptin on interaction between heregulin and erbB receptors HER3/HER2 by single-molecule force spectroscopy. 30 May 2009
• The role of genes involved in neuroplasticity and neurogenesis in the observation of a gene-environment interaction (GxE) in schizophrenia. 29 Apr 2009
• Animal models of gene-environment interactions in schizophrenia. 16 Apr 2009
• A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia. 3 Apr 2009
• The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain. 28 Mar 2009
• Update on key previously proposed candidate genes for schizophrenia. 27 Feb 2009
• The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants. 27 Feb 2009
• Nerve fibroblast impact on Schwann cell behavior. 23 Feb 2009
• Neuregulin 1, brain region specificity and PI3K/Akt in schizophrenia: comment on "Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal area". 15 Feb 2009
• [Association analysis of neuregulin 1 gene polymorphism with schizophrenia in Chinese Han population] 30 Jan 2009
• ErbB4 regulates surfactant synthesis and proliferation in adult rat pulmonary epithelial cells. 30 Jan 2009
• The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex. 13 Jan 2009
• Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis. 12 Jan 2009
• Neuregulin-1 signaling in schizophrenia: 'Jack of all trades' or master of some? 30 Dec 2008
• Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice. 23 Dec 2008

See a longer list of these articles.

Technical information about 'Neuregulin-1'

Definition: A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.

Registry Number: 0

Descriptor UI: D020890

Alternative terms: Neuregulin-1; Neuregulin 1; NDF Protein; NRG1 Protein; neu Differentiation Factor; Differentiation Factor, neu; Glial Growth Factor; GGF Protein; Heregulin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.860.550.750; D12.776.467.860.550.750; D12.776.641.600.550.750; D23.529.850.550.750;

History Note: 2000; use NEUREGULIN-1 (NM) 1993-1999; for GLIAL GROWTH FACTOR use GLIA MATURATION FACTOR (NM) 1980-1999

Technical Notes: do not confuse X ref GLIAL GROWTH FACTOR with GLIA MATURATION FACTOR