Neuregulin-1
Research News and Information

Sunday, November 22, 2009

HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells.

29 Nov 2009 HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key ... Read more...

A G protein-coupled receptor is essential for Schwann cells to initiate myelination.

9 Sep 2009 The myelin sheath allows axons to conduct action potentials rapidly in the vertebrate nervous system. Axonal signals activate expression of specific transcription factors, including Oct6 and Krox20, that initiate myelination in Schwann cells. ... Read more...

Propagation of spreading depression inversely correlates with cortical myelin content.

30 Aug 2009 OBJECTIVE: Cortical myelin can be severely affected in patients with demyelinating disorders of the central nervous system. However, the functional implication of cortical demyelination remains elusive. In this study, we investigated whether ... Read more...

Latest indexed articles for 'Neuregulin-1'

These are the very latest articles for this heading:

• HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells. 29 Nov 2009
• A G protein-coupled receptor is essential for Schwann cells to initiate myelination. 9 Sep 2009
• Propagation of spreading depression inversely correlates with cortical myelin content. 30 Aug 2009
• Journal club. A molecular cardiologist looks into getting to the heart of his inner fish. 25 Aug 2009
• Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. 24 Aug 2009
• LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression. Aug 2009
• Breaking the silence: stimulating proliferation of adult cardiomyocytes. 30 Jul 2009
• Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression. 30 Jul 2009
• ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia. 30 Jul 2009
• Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population. 30 Jul 2009
• Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. 28 Jul 2009
• Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. 21 Jul 2009
• Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. 11 Jul 2009
• [Signaling mechanism underlying myelination in peripheral nervous system] 29 Jun 2009
• Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study. 26 Jun 2009
• Cingulate white matter neurons in schizophrenia and bipolar disorder. 23 Jun 2009
• The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. 13 Jun 2009
• Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. 12 Jun 2009
• Neuregulin 1-stimulated phosphorylation of AKT in psychotic disorders and its relationship with neurocognitive functions. 9 Jun 2009
• Upregulation of NRG-1 and VAMP-1 in human brain aggregates exposed to clozapine. 5 Jun 2009

See a longer list of these articles.

Technical information about 'Neuregulin-1'

Definition: A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.

Registry Number: 0

Descriptor UI: D020890

Alternative terms: Neuregulin-1; Neuregulin 1; NDF Protein; NRG1 Protein; neu Differentiation Factor; Differentiation Factor, neu; Glial Growth Factor; GGF Protein; Heregulin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.860.550.750; D12.776.467.860.550.750; D12.776.641.600.550.750; D23.529.850.550.750;

History Note: 2000; use NEUREGULIN-1 (NM) 1993-1999; for GLIAL GROWTH FACTOR use GLIA MATURATION FACTOR (NM) 1980-1999

Technical Notes: do not confuse X ref GLIAL GROWTH FACTOR with GLIA MATURATION FACTOR