Neuregulins - Metabolism
Research News and Information

Sunday, November 22, 2009

Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation.

29 Jun 2009 The expression of myelination-associated genes (MGs) can be induced by cyclic adenosine monophosphate (cAMP) elevation in isolated Schwann cells (SCs). To further understand the effect of known SC mitogens in the regulation of SC differentiation, we ... Read more...

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors.

30 Jan 2009 In holometabolous insects, the adult appendages and internal organs form anew from larval progenitor cells during metamorphosis. As described here, the adult Drosophila midgut, including intestinal stem cells (ISCs), develops from adult midgut ... Read more...

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.

28 Jan 2009 Schwann cells develop from multipotent neural crest cells and form myelin sheaths around axons that allow rapid transmission of action potentials. Neuregulin signaling through the ErbB receptor regulates Schwann cell development; however, the ... Read more...

Latest indexed articles for 'Neuregulins - Metabolism'

These are the very latest articles for this heading:

• Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation. 29 Jun 2009
• EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. 30 Jan 2009
• Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. 28 Jan 2009
• ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. 24 Sep 2008
• Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons. Jul 2008
• Neuregulins and cancer. 30 May 2008
• Role of ErbB4 in breast cancer. May 2008
• The neuregulin family of genes and their multiple splice variants in breast cancer. 13 Apr 2008
• The ERBB3 receptor in cancer and cancer gene therapy. 9 Apr 2008
• Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. 3 Mar 2008
• Immunoexpression of HER family, neuregulin, MAPK and AKT in invasive ductal carcinomas of the breast. 30 Dec 2007
• Agrin and neuregulin, expanding roles and implications for therapeutics. 2 Dec 2007
• Dynamic expression of Erbb pathway members during early mammary gland morphogenesis. 23 Oct 2007
• Characterization of the cell membrane-associated products of the Neuregulin 4 gene. 4 Aug 2007
• Signal transduction in early heart development (II): ventricular chamber specification, trabeculation, and heart valve formation. 29 Jun 2007
• Culture conditions affect proliferative responsiveness of olfactory ensheathing glia to neuregulins. 29 Apr 2007
• The EGF receptor family: spearheading a merger of signaling and therapeutics. 18 Feb 2007
• Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brain. 3 Feb 2007
• Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. 30 Oct 2006
• Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells. 8 Aug 2006

See a longer list of these articles.

Technical information about 'Neuregulins'

Definition: A family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor (RECEPTORS, ERBB-2). Multiple variant forms of NEUREGULINS occur due to alternative splicing of their mRNAs. The NEUREGULINS include products from the three known genes (NGR1; NGR2 and NGR3).

Registry Number: 0

Descriptor UI: D020880

Alternative terms: Neuregulins; NRG Proteins; Neuronal Differentiation Factor, Cholinergic;

Related Mesh Headings: Receptor, erbB-2;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.860.550; D12.776.467.860.550; D12.776.641.600.550; D23.529.850.550;

History Note: 2000; use NEUREGULINS (NM) 1986-1999