Neuregulins
Research News and Information

Sunday, November 22, 2009

Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation.

29 Jun 2009 The expression of myelination-associated genes (MGs) can be induced by cyclic adenosine monophosphate (cAMP) elevation in isolated Schwann cells (SCs). To further understand the effect of known SC mitogens in the regulation of SC differentiation, we ... Read more...

Gene expression profiling of ErbB receptors and ligands in human meningiomas.

29 Jun 2009 ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied. Meningiomas represent 30% of primary cranial tumors, are mostly benign, and prevail in the second half of ... Read more...

[Interfering effect of neuregulin upon cerebral ischemic reperfusion injury in rhesus monkeys]

17 May 2009 OBJECTIVE: To study the interfering effect of neuregulin-1beta (NRG-1beta) on the cerebral ischemic reperfusion injury in monkeys. METHODS: The models with middle cerebral artery occlusion reperfusion (MCAO/R) were established by inserting a ... Read more...

Latest indexed articles for 'Neuregulins'

These are the very latest articles for this heading:

• Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation. 29 Jun 2009
• Gene expression profiling of ErbB receptors and ligands in human meningiomas. 29 Jun 2009
• [Interfering effect of neuregulin upon cerebral ischemic reperfusion injury in rhesus monkeys] 17 May 2009
• Signals of recent positive selection in a worldwide sample of human populations. 21 Mar 2009
• Neuregulin signaling is dispensable for NMDA- and GABA(A)-receptor expression in the cerebellum in vivo. 23 Feb 2009
• EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. 30 Jan 2009
• Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. 28 Jan 2009
• Expression of ErbB receptors and their cognate ligands in gastric and colon cancer cell lines. 30 Dec 2008
• Notch signalling coordinates tissue growth and wing fate specification in Drosophila. 3 Nov 2008
• ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. 24 Sep 2008
• The roles of pericystic cells and Sertoli cells in spermatogonial proliferation stimulated by some growth factors in organ culture of newt (Cynops pyrrhogaster) testis. 10 Aug 2008
• Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons. Jul 2008
• [Basic and clinical importance of nicotinic acetylcholine receptors] 29 Jun 2008
• Neuregulins and cancer. 30 May 2008
• Role of ErbB4 in breast cancer. May 2008
• The neuregulin family of genes and their multiple splice variants in breast cancer. 13 Apr 2008
• The ERBB3 receptor in cancer and cancer gene therapy. 9 Apr 2008
• Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. 3 Mar 2008
• Neuregulin blocks synaptic strengthening after epileptiform activity in the rat hippocampus. 27 Feb 2008
• [Effects of recombined neuregulin on healthy Macaca mulatta hearts] 30 Jan 2008

See a longer list of these articles.

Technical information about 'Neuregulins'

Definition: A family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor (RECEPTORS, ERBB-2). Multiple variant forms of NEUREGULINS occur due to alternative splicing of their mRNAs. The NEUREGULINS include products from the three known genes (NGR1; NGR2 and NGR3).

Registry Number: 0

Descriptor UI: D020880

Alternative terms: Neuregulins; NRG Proteins; Neuronal Differentiation Factor, Cholinergic;

Related Mesh Headings: Receptor, erbB-2;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.860.550; D12.776.467.860.550; D12.776.641.600.550; D23.529.850.550;

History Note: 2000; use NEUREGULINS (NM) 1986-1999