Neurodegenerative Diseases - Drug therapy
Research News and Information

Monday, November 23, 2009

The APCs of neuroprotection.

17 Oct 2009 Mutations in the enzyme superoxide dismutase 1 (SOD1) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this issue of the JCI, Zhong et al. report that the endogenous anticoagulant activated protein C (APC) is ... Read more...

Novel therapeutics based on tau/microtubule dynamics: WO2008084483.

30 Aug 2009 BACKGROUND: The present patent deals with the generation of peptides derived from the activity-dependent peptide and tau mimetic to study its effect on microtubule stability, its ability to bind to tubulin and MAPs, as well as promoting cell ... Read more...

Magnesium in acute and chronic brain injury: an update.

30 Aug 2009 While brain free magnesium levels have been shown to decline in a number of acute and chronic brain pathologies, the mechanisms of such decline and the potential for magnesium administration as a therapeutic intervention are still unclear. In acute ... Read more...

Latest indexed articles for 'Neurodegenerative Diseases - Drug therapy'

These are the very latest articles for this heading:

• The APCs of neuroprotection. 17 Oct 2009
• Novel therapeutics based on tau/microtubule dynamics: WO2008084483. 30 Aug 2009
• Magnesium in acute and chronic brain injury: an update. 30 Aug 2009
• The proteostasis boundary in misfolding diseases of membrane traffic. 18 Aug 2009
• List of drugs in development for neurodegenerative diseases: update June 2009. 6 Aug 2009
• GSK3 inhibitors and disease. 30 Jul 2009
• Pharmacological treatment of apathy in neurodegenerative diseases: a systematic review. 15 Jul 2009
• "Native-like aggregation" of the acylphosphatase from Sulfolobus solfataricus and its biological implications. 14 Jul 2009
• Metallothionein-I+II in neuroprotection. 29 Jun 2009
• Neurodegenerative disorders and nanoformulated drug development. 29 Jun 2009
• The multiple faces of quercetin in neuroprotection. 29 Jun 2009
• Ginseng compounds: an update on their molecular mechanisms and medical applications. 29 Jun 2009
• Development of vaccination approaches for the treatment of neurological diseases. 29 Jun 2009
• Chelation therapy for neurodegenerative diseases. 29 Jun 2009
• Creating zinc monkey wrenches in the treatment of epigenetic disorders. 19 Jun 2009
• The basics of preclinical drug development for neurodegenerative disease indications. 10 Jun 2009
• Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration. 4 Jun 2009
• From endocannabinoid profiling to 'endocannabinoid therapeutics'. Jun 2009
• Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium. 30 May 2009
• Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. 30 May 2009

See a longer list of these articles.

Technical information about 'Neurodegenerative Diseases'

Definition: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Descriptor UI: D019636

Alternative terms: Neurodegenerative Diseases; Neurodegenerative Disease; Degenerative Diseases, Neurologic; Neurologic Degenerative Disease; Degenerative Neurologic Diseases; Degenerative Neurologic Disease; Neurologic Disease, Degenerative; Neurologic Diseases, Degenerative; Nervous System Degenerative Diseases; Neurodegenerative Disorders; Neurodegenerative Disorder; Neurologic Degenerative Conditions; Degenerative Condition, Neurologic; Degenerative Conditions, Neurologic; Neurologic Degenerative Condition; Neurologic Degenerative Diseases; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Degenerative Neurologic Disorder; Neurologic Disorder, Degenerative; Neurologic Disorders, Degenerative; Degenerative Diseases, Spinal Cord; Degenerative Diseases, Central Nervous System;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.574;

History Note: 98

Technical Notes: GEN or unspecified; prefer specifics; /genet: consider also HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM