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Neurofilament Proteins
Research News and Information
Definition of 'Neurofilament Proteins'Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302) |
Sunday, November 22, 2009
Biomarkers in the cerebrospinal fluid and neurodegeneration in Langerhans cell histiocytosis.
13 Dec 2009 
BACKGROUND: Progressive neurodegeneration may result in potentially severe cognitive and motor dysfunctions as a complication of Langerhans cell histiocytosis (LCH), a suggested IL-17A-associated inflammatory condition. To detect this complication ... Read more...
From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior.
30 Oct 2009 The prognosis in children harboring a glioblastoma multiforme (GBM) is usually poor. Few GBMs in children, however, seem to respond quite well to adjuvant chemotherapy. The biological basis for such chemotherapy sensitivity remains uncertain. In ... Read more...
30 Oct 2009 The Ser493 residue in the E-segment of the rat neurofilament heavy chain (NF-H) is phosphorylated by glycogen synthase kinase 3beta (GSK3 beta) in vitro and in spinal cord. We examined Ser493 phosphorylation by analyzing developmental changes and ... Read more...
Latest indexed articles for 'Neurofilament Proteins'
These are the very latest articles for this heading:
- Biomarkers in the cerebrospinal fluid and neurodegeneration in Langerhans cell histiocytosis. 13 Dec 2009
- From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior. 30 Oct 2009
- Novel axonal distribution of neurofilament-H phosphorylated at the glycogen synthase kinase 3beta-phosphorylation site in its E-segment. 30 Oct 2009
- A compact STED microscope providing 3D nanoscale resolution. 29 Sep 2009
- Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. 26 Sep 2009
- Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. 14 Sep 2009
- Neurofilaments bind tubulin and modulate its polymerization. 31 Aug 2009
- Antibodies to neurofilaments. 30 Aug 2009
- Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation? 30 Aug 2009
- MSC p43 required for axonal development in motor neurons. 24 Aug 2009
- Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability. Aug 2009
- Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders. 30 Jul 2009
- Native like structure in the unfolded state of the villin headpiece helical subdomain, an ultrafast folding protein. 30 Jul 2009
- Enhanced microglial clearance of myelin debris in T cell-infiltrated central nervous system. 30 Jul 2009
- Evidence that anterior episcleral nerve sheath tumors arise from the Axenfeld nerve loop.
30 Jul 2009 - Architectonic subdivisions of neocortex in the tree shrew (Tupaia belangeri). 29 Jun 2009
- Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. 29 Jun 2009
- CSF protein biomarkers for proximal axonal damage improve prognostic accuracy in the acute phase of Guillain-Barré syndrome. 29 Jun 2009
- Dysfunctions of neuronal and glial intermediate filaments in disease. 29 Jun 2009
- Phenylmethylsulfonyl fluoride protects against the degradation of neurofilaments in tri-ortho-cresyl phosphate (TOCP) induced delayed neuropathy. 28 Jun 2009
See a longer list of these articles.
Technical information about 'Neurofilament Proteins'
Definition: Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
Registry Number: 0
Descriptor UI: D016900
Alternative terms: Neurofilament Proteins; Proteins, Neurofilament; Heavy Neurofilament Protein; Neurofilament Protein, Heavy; Protein, Heavy Neurofilament; Neurofilament Triplet Proteins; Proteins, Neurofilament Triplet; Triplet Proteins, Neurofilament;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D05.750.078.593.630; D12.776.220.475.630; D12.776.641.630;
Online Note: use NEUROFILAMENT PROTEINS (NM) to search NEUROFILAMENT PROTEINS 1977-91
History Note: 92; was NEUROFILAMENT PROTEINS (NM) 1977-91
Technical Notes: /biosyn /physiol permitted