Neurogenesis - Drug effects
Research News and Information

Saturday, November 21, 2009

The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation.

30 Oct 2009 PURPOSE: Whole-brain irradiation (WBI) leads to cognitive impairment months to years after radiation. Numerous studies suggest that decreased hippocampal neurogenesis and microglial activation are involved in the pathogenesis of WBI-induced brain ... Read more...

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.

22 Sep 2009 Disrupted-in-schizophrenia 1 (DISC1), a susceptibility gene for major mental illnesses, regulates multiple aspects of embryonic and adult neurogenesis. Here, we show that DISC1 suppression in newborn neurons of the adult hippocampus leads to ... Read more...

Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals.

16 Sep 2009 This study was initiated to find small molecule ligands that would induce a functional response when docked with neurotrophin Trk receptors. "Minimalist" mimics of beta-turns were designed for this purpose. These mimics are (i) rigid, yet easily ... Read more...

Latest indexed articles for 'Neurogenesis - Drug effects'

These are the very latest articles for this heading:

• The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. 30 Oct 2009
• DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. 22 Sep 2009
• Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals. 16 Sep 2009
• Netrin participates in the development of retinotectal synaptic connectivity by modulating axon arborization and synapse formation in the developing brain. 7 Sep 2009
• Prenatal phencyclidine exposure alters hippocampal cell proliferation in offspring rats. 30 Aug 2009
• Protection of neurons derived from human neural progenitor cells by veratridine. 24 Aug 2009
• 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. 3 Aug 2009
• Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus. 30 Jul 2009
• Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis. 30 Jul 2009
• The Alzheimer's disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus. 30 Jul 2009
• Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage. 28 Jul 2009
• Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro. 28 Jul 2009
• Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. 16 Jul 2009
• The effect of interferon-beta on mouse neural progenitor cell survival and differentiation. 16 Jul 2009
• Maximum-entropy network analysis reveals a role for tumor necrosis factor in peripheral nerve development and function. 11 Jul 2009
• Decreased cell proliferation in the dentate gyrus does not associate with development of anhedonic-like symptoms in rats. 8 Jul 2009
• Strategies to promote differentiation of newborn neurons into mature functional cells in Alzheimer brain. 7 Jul 2009
• An unexpected effect of 5-MCA-NAT in chick retinal development. 7 Jul 2009
• Effects of repeated citalopram treatment on kainic acid-induced neurogenesis in adult mouse hippocampus. 7 Jul 2009
• MK801-induced activated caspase-3 exhibits selective co-localization with GAD67. 7 Jul 2009

See a longer list of these articles.

Technical information about 'Neurogenesis'

Definition: Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.

Descriptor UI: D055495

Alternative terms: Neurogenesis; Neurogeneses;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G04.299.151.912; G07.700.320.500.325.377.687; G08.686.785.760.170.450.500;

History Note: 2009