Neurogranin - Genetics
Research News and Information

Sunday, November 22, 2009

Neurogranin enhances synaptic strength through its interaction with calmodulin.

25 Aug 2009 Learning-correlated plasticity at CA1 hippocampal excitatory synapses is dependent on neuronal activity and NMDA receptor (NMDAR) activation. However, the molecular mechanisms that transduce plasticity stimuli to postsynaptic potentiation are poorly ... Read more...

Common variants conferring risk of schizophrenia.

29 Jun 2009 Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. ... Read more...

Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis.

15 Apr 2009 Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca(2+)-levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We ... Read more...

Latest indexed articles for 'Neurogranin - Genetics'

These are the very latest articles for this heading:

• Neurogranin enhances synaptic strength through its interaction with calmodulin. 25 Aug 2009
• Common variants conferring risk of schizophrenia. 29 Jun 2009
• Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis. 15 Apr 2009
• Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system. 30 Jan 2009
• Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). 13 Oct 2008
• The effects of retinoic acid on the expression of neurogranin after experimental cerebral ischemia. 18 Jun 2008
• Developmental exposure to pentachlorophenol affects the expression of thyroid hormone receptor beta1 and synapsin I in brain, resulting in thyroid function vulnerability in rats. 30 May 2008
• Polychlorinated biphenyls (Aroclor 1254) do not uniformly produce agonist actions on thyroid hormone responses in the developing rat brain. 15 Apr 2008
• Expression of PKC substrate proteins, GAP-43 and neurogranin, is downregulated by cAMP signaling and alterations in synaptic activity. 12 Nov 2007
• IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin. 22 Oct 2007
• Long-term enrichment enhances the cognitive behavior of the aging neurogranin null mice without affecting their hippocampal LTP. 30 Jul 2007
• Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development. 27 Feb 2007
• Characterization of transcriptional regulation of neurogranin by nitric oxide and the role of neurogranin in SNP-induced cell death: implication of neurogranin in an increased neuronal susceptibility to oxidative stress. 21 Feb 2007
• Effects of perinatal exposure to low-dose cadmium on thyroid hormone-related and sex hormone receptor gene expressions in brain of offspring. 20 Feb 2007
• Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. 20 Feb 2007
• Disruption of acute opioid dependence by antisense oligodeoxynucleotides targeting neurogranin. 23 Jan 2007
• Association of the gene encoding neurogranin with schizophrenia in males. 28 Nov 2006
• Attenuation of opioid tolerance by antisense oligodeoxynucleotides targeting neurogranin. 18 May 2006
• Involvement of the GC-rich sequence and specific proteins (Sp1/Sp3) in the basal transcription activity of neurogranin gene. 23 Apr 2006
• Northern blot and in situ hybridization analyses for the neurogranin mRNA in the developing monkey cerebral cortex. 21 Feb 2006

See a longer list of these articles.

Technical information about 'Neurogranin'

Definition: A BRAIN-specific substrate for PROTEIN KINASE C that binds CALMODULIN and is involved in regulation of CALCIUM SIGNALING.

Registry Number: 132654-77-4

Descriptor UI: D051579

Alternative terms: Neurogranin; RC3 Protein (Neurogranin); P17 Protein Kinase C Substrate;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.142.500; D12.776.641.640;

History Note: 2006(1991)