Neurogranin - Metabolism
Research News and Information

Sunday, November 22, 2009

Neurogranin enhances synaptic strength through its interaction with calmodulin.

25 Aug 2009 Learning-correlated plasticity at CA1 hippocampal excitatory synapses is dependent on neuronal activity and NMDA receptor (NMDAR) activation. However, the molecular mechanisms that transduce plasticity stimuli to postsynaptic potentiation are poorly ... Read more...

Increased phosphorylation of Ets-like transcription factor-1 in neurons of hypoxic preconditioned mice.

17 Feb 2009 Ets-like transcription factor-1 (Elk-1) is a target of mitogen activated protein kinase (MAPK) which has been reported to play a key role in the induction of tolerance to ischemic and hypoxic injury, but little is known about the role of Elk-1 in ... Read more...

Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system.

30 Jan 2009 Songbirds are appreciated for the insights they provide into regulated neural plasticity. Here, we describe the comparative analysis and brain expression of two gene sequences encoding probable regulators of synaptic plasticity in songbirds: ... Read more...

Latest indexed articles for 'Neurogranin - Metabolism'

These are the very latest articles for this heading:

• Long-term potentiation: two pathways meet at neurogranin. 5 Oct 2009
• Neurogranin enhances synaptic strength through its interaction with calmodulin. 25 Aug 2009
• Increased phosphorylation of Ets-like transcription factor-1 in neurons of hypoxic preconditioned mice. 17 Feb 2009
• Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system. 30 Jan 2009
• Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3'-triiodo-L-thyronine. 13 Jan 2009
• Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. 20 Aug 2008
• The effects of retinoic acid on the expression of neurogranin after experimental cerebral ischemia. 18 Jun 2008
• T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behavior. 2 Jun 2008
• Peony root extract upregulates transthyretin and phosphoglycerate mutase in mouse cobalt focus seizure. 26 Apr 2008
• Polychlorinated biphenyls (Aroclor 1254) do not uniformly produce agonist actions on thyroid hormone responses in the developing rat brain. 15 Apr 2008
• Evidence of altered calmodulin immunoreactivity in areas 9 and 32 of schizophrenic prefrontal cortex. 2 Mar 2008
• Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway. 25 Feb 2008
• Expression of PKC substrate proteins, GAP-43 and neurogranin, is downregulated by cAMP signaling and alterations in synaptic activity. 12 Nov 2007
• IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin. 22 Oct 2007
• Neurogranin controls the spatiotemporal pattern of postsynaptic Ca2+/CaM signaling. 15 Aug 2007
• Neuron-specific phosphorylation of c-Jun N-terminal kinase increased in the brain of hypoxic preconditioned mice. 31 Jul 2007
• Long-term enrichment enhances the cognitive behavior of the aging neurogranin null mice without affecting their hippocampal LTP. 30 Jul 2007
• Neuron-specific phosphorylation of mitogen- and stress-activated protein kinase-1 involved in cerebral hypoxic preconditioning of mice. 29 Apr 2007
• Proteomics analysis of the expression of neurogranin in murine neuroblastoma (Neuro-2a) cells reveals its involvement for cell differentiation. 17 Apr 2007
• Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Apr 2007

See a longer list of these articles.

Technical information about 'Neurogranin'

Definition: A BRAIN-specific substrate for PROTEIN KINASE C that binds CALMODULIN and is involved in regulation of CALCIUM SIGNALING.

Registry Number: 132654-77-4

Descriptor UI: D051579

Alternative terms: Neurogranin; RC3 Protein (Neurogranin); P17 Protein Kinase C Substrate;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.142.500; D12.776.641.640;

History Note: 2006(1991)