Neuromuscular Junction - Genetics
Research News and Information

Saturday, November 21, 2009

Autophagy promotes synapse development in Drosophila.

26 Sep 2009 Autophagy, a lysosome-dependent degradation mechanism, mediates many biological processes, including cellular stress responses and neuroprotection. In this study, we demonstrate that autophagy positively regulates development of the Drosophila ... Read more...

[Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse]

30 Jul 2009 Neuromuscular junction is a prototypical synapse, and most synaptic molecules expressed in the central nervous system have been first identified at the neuromuscular junction. Congenital myasthenic syndromes are caused by genetic defects of ... Read more...

Identification of an agrin mutation that causes congenital myasthenia and affects synapse function.

21 Jul 2009 We report the case of a congenital myasthenic syndrome due to a mutation in AGRN, the gene encoding agrin, an extracellular matrix molecule released by the nerve and critical for formation of the neuromuscular junction. Gene analysis identified a ... Read more...

Latest indexed articles for 'Neuromuscular Junction - Genetics'

These are the very latest articles for this heading:

• Autophagy promotes synapse development in Drosophila. 26 Sep 2009
• [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse] 30 Jul 2009
• A treatable muscle disease. 30 Jul 2009
• Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. 21 Jul 2009
• Deal breaker: semaphorin and specificity in the spinal stretch reflex circuit. 14 Jul 2009
• Zebrafish survival motor neuron mutants exhibit presynaptic neuromuscular junction defects. 8 Jul 2009
• On the mechanism of action of muscle fibre activity in synapse competition and elimination at the mammalian neuromuscular junction. 27 May 2009
• Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission. 29 Apr 2009
• Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. 27 Apr 2009
• The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor subunit composition. 27 Apr 2009
• Mammalian neuromuscular junctions: modern tools to monitor synaptic form and function. 21 Apr 2009
• Aberrant development of neuromuscular junctions in glycosylation-defective Large(myd) mice. 3 Apr 2009
• HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans. 30 Mar 2009
• Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding. 30 Mar 2009
• Temporal dynamics of neuronal activation by Channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae. 30 Mar 2009
• Functional and morphological evidence of age-related denervation in rat laryngeal muscles. 15 Feb 2009
• ben Functions with scamp during synaptic transmission and long-term memory formation in Drosophila. 12 Jan 2009
• HLA class II allele analysis in MuSK-positive myasthenia gravis suggests a role for DQ5. 11 Jan 2009
• A modified acetylcholine receptor delta-subunit enables a null mutant to survive beyond sexual maturation. Dec 2008
• Metabotropic glutamate receptor-mediated use-dependent down-regulation of synaptic excitability involves the fragile X mental retardation protein. 24 Nov 2008

See a longer list of these articles.

Technical information about 'Neuromuscular Junction'

Definition: The synapse between a neuron and a muscle.

Descriptor UI: D009469

Alternative terms: Neuromuscular Junction; Junction, Neuromuscular; Junctions, Neuromuscular; Neuromuscular Junctions; Myoneural Junction; Junction, Myoneural; Junctions, Myoneural; Myoneural Junctions; Nerve-Muscle Preparation; Nerve Muscle Preparation; Nerve-Muscle Preparations; Preparation, Nerve-Muscle; Preparations, Nerve-Muscle;

Related Mesh Headings: Neuromuscular Blocking Agents; Neuromuscular Depolarizing Agents; Receptors, Cholinergic;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; ultrastructure; ultrasonography; chemistry; virology; genetics;

Tree Number: A08.800.550.550.550; A08.850.550.550; A11.284.149.165.420.780.550.550;

Online Note: use NEUROMUSCULAR JUNCTION to search MYONEURAL JUNCTION 1966-67

History Note: 68; was MYONEURAL JUNCTION 1963-67

Technical Notes: /drug eff: consider also NEUROMUSCULAR BLOCKING AGENTS or NEUROMUSCULAR DEPOLARIZING AGENTS; neuromusc transm = NEUROMUSCULAR JUNCTION /physiol + NEURAL TRANSMISSION; dis = NEUROMUSCULAR JUNCTION DISEASES